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Inferring single-cell and spatial microRNA activity from transcriptomics data
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DOI：10.1038/s42003-025-07454-9.png)
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摘要
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The activity of miRNA varies across different cell populations and systems, as part of the mechanisms that distinguish cell types and roles in living organisms and in human health and disease. Typically, miRNA regulation drives changes in the composition and levels of protein-coding RNA and of lncRNA, with targets being down-regulated when miRNAs are active. The term miRNA activity is used to refer to this transcriptional effect of miRNAs. This study introduces miTEA-HiRes, a method designed to facilitate the evaluation of miRNA activity at high resolution. The method applies to single-cell transcriptomics, type-specific single-cell populations, and spatial transcriptomics data. By comparing different conditions, differential miRNA activity is inferred. For instance, miTEA-HiRes analysis of peripheral blood mononuclear cells comparing Multiple Sclerosis patients to control groups revealed differential activity of miR-20a-5p and others, consistent with the literature on miRNA underexpression in Multiple Sclerosis. We also show miR-519a-3p differential activity in specific cell populations.
Keyword:
THERAPEUTIC TARGETS
MULTIPLE-SCLEROSIS
MESSENGER-RNA
BREAST-CANCER
RANKED LISTS
EXPRESSION
IDENTIFICATION
PROLIFERATION
PROTEIN
MIRNAS
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期刊
IF:
5.1
论文数:
1.0W
被引数:
3.2W
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