.png){kind=icon}
返回
Inflammatory disease and cancer with a decrease in Kupffer cell numbers in Nucling-knockout mice
.png){kind=icon}
OA
AI
DOI：10.1002/ijc.24789.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Nucling is a stress-inducible protein associated with apoptosomes. The cytochrome c-triggered formation of apoptosomes represents a key-initiating event in apoptosis. We have recently reported that Nucling regulates the apoptotic pathway by controlling the activation of NF-kappa B as well. Here we show that hepatocellular carcinoma (HCC) arising spontaneously against a background of hepatitis occurred more frequently in Nucling-knockout (KO) mice than wild-type (WT) mice. Biochemical serum testing revealed potential liver dysfunction with hypercholesterolemia in Nucling-KO mates. In the background of Nucling-KO mice, we observed the up-regulation of TNF alpha, spontaneous NF-kappa B-activation and the induction of galectin-3 expression in liver. In addition, we observed a decrease in the number of Kupffer cells (KCs) in the KO mice. KCs are important for the hepatic immune system, acting as phagocytes or antigen-presenting cells (APCs). We found that KCs in Nucling-KO mice were apoptotic possibly through the up-regulation of TNF alpha. These observations indicate that Nucling is important for the regulation of NF-kappa B signals in liver. We propose that Nucling deficiency could be a powerful tool to reveal the NF-kappa B-related molecular networks leading to hepatitis and HCC development.
Keyword:
Nucling
inflammation
hepatocellular carcinoma
Kupffer cell
NF-kappa B
apoptosis
tumorigenesis
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
4.7
论文数:
2.0W
被引数:
4.9W
机构
引用论文
Phosphorylation of threonine 154 in p40phox is an important physiological signal for activation of the neutrophil NADPH oxidase.png)
BloodOAAI
BloodIF0
OAAI分享收藏Salutary effects of an attention bias modification mobile application on biobehavioral measures of stress and anxiety during pregnancy注意偏差修改移动应用程序对怀孕期间压力和焦虑的生物行为测量的有益影响OAAI
OAAI分享收藏分享收藏
查看更多内容