Know your target, know your molecule

doi:10.1038/nchembio.1813

2015-05-15

PRE

DOI：10.1038/nchembio.1813

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摘要

En 中文

The pharmaceutical industry continues to experience significant attrition of drug candidates during phase 2 proof-of-concept clinical studies. We describe some questions about the characteristics of protein targets and small-molecule drugs that may be important to consider in drug-discovery projects and could improve prospects for future clinical success.

Keyword:

INHIBITORS

SELECTIVITY

DISCOVERY

BIOLOGY

GROWTH

POTENT

PROBES

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期刊

Nature Chemical Biology

IF:

13.7

论文数:

4.8K

被引数:

3.3W

机构

Pfizer

学者数:

2.3W

论文数: 1.2W

被引数: 22

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