未登录 Deep functional measurements of Fragile X syndrome human neurons reveal multiparametric electrophysiological disease phenotype Fink, James J.; Delaney-Busch, Nathaniel; Dawes, Ryan; Nanou, Evanthia; Folts, Christopher; Harikrishnan, Karthiayani; Hempel, Chris; Upadhyay, Hansini; Nguyen, Trinh; Shroff, Himali; Stoppel, David; Ryan, Steven J.; Jacques, Jane; Grooms, Jennifer; Berry-Kravis, Elizabeth; Bear, Mark F.; Williams, Luis A.; Gerber, David; Bunnage, Mark; Furey, Brinley; Dempsey, Graham T. 分享 收藏
Inaxaplin for Proteinuric Kidney Disease in Persons with Two APOL1 Variants Egbuna, Ogo; Zimmerman, Brandon; Manos, George; Fortier, Anne; Chirieac, Madalina C.; Dakin, Leslie A.; Friedman, David J.; Bramham, Kate; Campbell, Kirk; Knebelmann, Bertrand; Barisoni, Laura; Falk, Ronald J.; Gipson, Debbie S.; Lipkowitz, Michael S.; Ojo, Akinlolu; Bunnage, Mark E.; Pollak, Martin R.; Altshuler, David; Chertow, Glenn M. 分享 收藏
Discovery of Novel, Orally Bioavailable Pyrimidine Ether-Based Inhibitors of ELOVL1 Boyd, Michael J.; Collier, Philip N.; Clark, Michael P.; Deng, Hongbo; Kesavan, Sarathy; Ronkin, Steven M.; Waal, Nathan; Wang, Jian; Cao, Jingrong; Li, Pan; Come, Jon; Davies, Ioana; Duffy, John P.; Cochran, John E.; Court, John J.; Chandupatla, Kishan; Jackson, Katrina L.; Maltais, Francois; O'Dowd, Hardwin; Boucher, Christina; Considine, Tony; Taylor, William P.; Gao, Hong; Chakilam, Ananthisrinivas; Engtrakul, Juntyma; Crawford, Dan; Doyle, Elizabeth; Phillips, Jonathan; Kemper, Raymond; Swett, Rebecca; Empfield, James; Bunnage, Mark E.; Charifson, Paul S.; Magavi, Sanjay Shivayogi 分享 收藏
Discovery and Optimization of Pyrazole Amides as Inhibitors of ELOVL1 Come, Jon H.; Senter, Timothy J.; Clark, Michael P.; Court, John J.; Gale-Day, Zachary; Gu, Wenxin; Krueger, Elaine; Liang, Jianglin; Morris, Mark; Nanthakumar, Suganthini; O'Dowd, Hardwin; Maltais, Francois; Iyer, Ganesh; Andreassi, John; Boucher, Christina; Considine, Tony; Moody, Cameron S.; Taylor, William; Mohanty, Arun K.; Huang, Yulin; Zuccola, Harmon; Coll, Joyce; Bonanno, Kenneth C.; Gagnon, Kevin J.; Gan, Lu; Lu, Fan; Gao, Hong; Chakilam, Ananthisrinivas; Engtrakul, Juntyma; Song, Bin; Crawford, Dan; Doyle, Elisabeth; Kramer, Tal; Vought, Bryan; Phillips, Jonathan; Kemper, Raymond; Sanders, Martin; Swett, Rebecca; Furey, Brinley; Winquist, Ray; Bunnage, Mark E.; Jackson, Katrina L.; Charifson, Paul S.; Magavi, Sanjay S. 分享 收藏
Microfluidic-Enabled Intracellular Delivery of Membrane Impermeable Inhibitors to Study Target Engagement in Human Primary Cells Li, Jing; Wang, Bu; Juba, Brian M.; Vazquez, Michael; Kortum, Steve W.; Pierce, Betsy S.; Pacheco, Michael; Roberts, Lee; Strohbach, Joseph W.; Jones, Lyn H.; Hett, Erik; Thorarensen, Atli; Telliez, Jean-Baptiste; Sharei, Armon; Bunnage, Mark; Gilbert, Jonathan Brian 分享 收藏
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Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists Liu, Shenping; Dakin, Leslie A.; Xing, Li; Withka, Jane M.; Sahasrabudhe, Parag V.; Li, Wei; Banker, Mary Ellen; Balbo, Paul; Shanker, Suman; Chrunyk, Boris A.; Guo, Zuojun; Chen, Jinshan M.; Young, Jennifer A.; Bai, Guoyun; Starr, Jeremy T.; Wright, Stephen W.; Bussenius, Joerg; Tan, Sheng; Gopalsamy, Ariamala; Lefker, Bruce A.; Vincent, Fabien; Jones, Lyn H.; Xu, Hua; Hoth, Lise R.; Geoghegan, Kieran F.; Qiu, Xiayang; Bunnage, Mark E.; Thorarensen, Atli 分享 收藏
Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit Gerstenberger, Brian S.; Trzupek, John D.; Tallant, Cynthia; Fedorov, Oleg; Filippakopoulos, Panagis; Brennan, Paul E.; Fedele, Vita; Martin, Sarah; Picaud, Sarah; Rogers, Catherine; Parikh, Mihir; Taylor, Alexandria; Samas, Brian; O'Mahony, Alison; Berg, Ellen; Pallares, Gabriel; Torrey, Adam D.; Treiber, Daniel K.; Samardjiev, Ivan J.; Nasipak, Brian T.; Padilla-Benavides, Teresita; Wu, Qiong; Imbalzano, Anthony N.; Nickerson, Jeffrey A.; Bunnage, Mark E.; Muller, Susanne; Knapp, Stefan; Owen, Dafydd R. 分享 收藏
Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance Fedorov, Oleg; Castex, Josefina; Tallant, Cynthia; Owen, Dafydd R.; Martin, Sarah; Aldeghi, Matteo; Monteiro, Octovia; Filippakopoulos, Panagis; Picaud, Sarah; Trzupek, John D.; Gerstenberger, Brian S.; Bountra, Chas; Willmann, Dominica; Wells, Christopher; Philpott, Martin; Rogers, Catherine; Biggin, Philip C.; Brennan, Paul E.; Bunnage, Mark E.; Schuele, Roland; Guenther, Thomas; Knapp, Stefan; Mueller, Susanne 分享 收藏
The promise and peril of chemical probes (vol 11, pg 536, 2015) Arrowsmith, Cheryl H.; Audia, James E.; Austin, Christopher; Baell, Jonathan; Bennett, Jonathan; Blagg, Julian; Bountra, Chas; Brennan, Paul E.; Brown, Peter J.; Bunnage, Mark E.; Buser-Doepner, Carolyn; Campbell, Robert M.; Carter, Adrian J.; Cohen, Philip; Copeland, Robert A.; Cravatt, Ben; Dahlin, Jayme L.; Dhanak, Dashyant; Edwards, Aled M.; Frederiksen, Mathias; Frye, Stephen V.; Gray, Nathanael; Grimshaw, Charles E.; Hepworth, David; Howe, Trevor; Huber, Kilian V. M.; Jin, Jian; Knapp, Stefan; Kotz, Joanne D.; Kruger, Ryan G.; Lowe, Derek; Mader, Mary M.; Marsden, Brian; Mueller-Fahrnow, Anke; Mueller, Susanne; O'Hagan, Ronan C.; Overington, John P.; Owen, Dafydd R.; Rosenberg, Saul H.; Ross, Ruth; Roth, Bryan; Schapira, Matthieu; Schreiber, Stuart L.; Shoichet, Brian; Sundstroem, Michael; Superti-Furga, Giulio; Taunton, Jack; Toledo-Sherman, Leticia; Walpole, Chris; Walters, Michael A.; Willson, Timothy M.; Workman, Paul; Young, Robert N.; Zuercher, William J. 分享 收藏
The promise and peril of chemical probes 化学探针的前景与危险 Arrowsmith, Cheryl H.; Audia, James E.; Austin, Christopher; Baell, Jonathan; Bennett, Jonathan; Blagg, Julian; Bountra, Chas; Brennan, Paul E.; Brown, Peter J.; Bunnage, Mark E.; Buser-Doepner, Carolyn; Campbell, Robert M.; Carter, Adrian J.; Cohen, Philip; Copeland, Robert A.; Cravatt, Ben; Dahlin, Jayme L.; Dhanak, Dashyant; Edwards, Aled M.; Frye, Stephen V.; Gray, Nathanael; Grimshaw, Charles E.; Hepworth, David; Howe, Trevor; Huber, Kilian V. M.; Jin, Jian; Knapp, Stefan; Kotz, Joanne D.; Kruger, Ryan G.; Lowe, Derek; Mader, Mary M.; Marsden, Brian; Mueller-Fahrnow, Anke; Mueller, Susanne; O'Hagan, Ronan C.; Overington, John P.; Owen, Dafydd R.; Rosenberg, Saul H.; Roth, Brian; Ross, Ruth; Schapira, Matthieu; Schreiber, Stuart L.; Shoichet, Brian; Sundstrom, Michael; Superti-Furga, Giulio; Taunton, Jack; Toledo-Sherman, Leticia; Walpole, Chris; Walters, Michael A.; Willson, Timothy M.; Workman, Paul; Young, Robert N.; Zuercher, William J. 分享 收藏
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Preclinical target validation using patient-derived cells 使用患者来源的细胞进行临床前目标验证 Edwards, Aled M.; Arrowsmith, Cheryl H.; Bountra, Chas; Bunnage, Mark E.; Feldmann, Marc; Knight, Julian C.; Patel, Dhavalkumar D.; Prinos, Panagiotis; Taylor, Michael D.; Sundstrom, Michael 分享 收藏
(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells Barsyte-Lovejoy, Dalia; Li, Fengling; Oudhoff, Menno J.; Tatlock, John H.; Dong, Aiping; Zeng, Hong; Wu, Hong; Freeman, Spencer A.; Schapira, Matthieu; Senisterra, Guillermo A.; Kuznetsova, Ekaterina; Marcellus, Richard; Allali-Hassani, Abdellah; Kennedy, Steven; Lambert, Jean-Philippe; Couzens, Amber L.; Aman, Ahmed; Gingras, Anne-Claude; Al-Awar, Rima; Fish, Paul V.; Gerstenberger, Brian S.; Roberts, Lee; Benn, Caroline L.; Grimley, Rachel L.; Braam, Mitchell J. S.; Rossi, Fabio M. V.; Sudol, Marius; Brown, Peter J.; Bunnage, Mark E.; Owen, Dafydd R.; Zaph, Colby; Vedadi, Masoud; Arrowsmith, Cheryl H. 分享 收藏
Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains Hay, Duncan A.; Fedorov, Oleg; Martin, Sarah; Singleton, Dean C.; Tallant, Cynthia; Wells, Christopher; Picaud, Sarah; Philpott, Martin; Monteiro, Octovia P.; Rogers, Catherine M.; Conway, Stuart J.; Rooney, Timothy P. C.; Tumber, Anthony; Yapp, Clarence; Filippakopoulos, Panagis; Bunnage, Mark E.; Mueller, Susanne; Knapp, Stefan; Schofield, Christopher J.; Brennan, Paul E. 分享 收藏
PFI-1, a Highly Selective Protein Interaction Inhibitor, Targeting BET Bromodomains PFI-1，一种高选择性蛋白质相互作用抑制剂，靶向BET溴结构域 Picaud, Sarah; Da Costa, David; Thanasopoulou, Angeliki; Filippakopoulos, Panagis; Fish, Paul V.; Philpott, Martin; Fedorov, Oleg; Brennan, Paul; Bunnage, Mark E.; Owen, Dafydd R.; Bradner, James E.; Taniere, Philippe; O'Sullivan, Brendan; Mueller, Susanne; Schwaller, Juerg; Stankovic, Tatjana; Knapp, Stefan 分享 收藏
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Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit Fish, Paul V.; Filippakopoulos, Panagis; Bish, Gerwyn; Brennan, Paul E.; Bunnage, Mark E.; Cook, Andrew S.; Federov, Oleg; Gerstenberger, Brian S.; Jones, Hannah; Knapp, Stefan; Marsden, Brian; Nocka, Karl; Owen, Dafydd R.; Philpott, Martin; Picaud, Sarah; Primiano, Michael J.; Ralph, Michael J.; Sciammetta, Nunzio; Trzupek, John D. 分享 收藏
The discovery of UK-369003, a novel PDE5 inhibitor with the potential for oral bioavailability and dose-proportional pharmacokinetics Rawson, David J.; Ballard, Stephen; Barber, Christopher; Barker, Laura; Beaumont, Kevin; Bunnage, Mark; Cole, Susan; Corless, Martin; Denton, Stephen; Ellis, David; Floc'h, Marion; Foster, Laura; Gosset, James; Holmwood, Frances; Lane, Charlotte; Leahy, David; Mathias, John; Maw, Graham; Million, William; Poinsard, Cedric; Price, Jenny; Russel, Rachel; Street, Stephen; Watson, Lesa 分享 收藏
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