Localization-dictated function for METTL3

Sylvain Delaunay

doi:10.1038/s41556-022-00972-2

2022-08-04

PRE

Sylvain Delaunay

Michaela Frye *

DOI：10.1038/s41556-022-00972-2

原文链接

摘要

En 中文

Aberrant subcellular localization of proteins contributes to the pathogenesis of cancer. A study now reports that the mis-localization of METTL3, a nuclear N-6-adenosine methyltransferase, to the cytoplasm promotes gastric cancer by enhancing mRNA translation of a subset of oncogenes, independently of the N-6-methyladenosine (m(6)A) modification.

Keyword:

MESSENGER-RNA

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期刊

Nature Cell Biology

IF:

19.1

论文数:

6.2K

被引数:

4.8W

机构

Helmholtz Association

学者数:

1.1K

论文数: 363

被引数: 0

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