Making ends meet in class switch recombination

Lizhen Wu

doi:10.1038/s41422-020-0342-5

2020-05-25

Lizhen Wu

David G. Schatz *

DOI：10.1038/s41422-020-0342-5

原文链接

查看原文

摘要

En 中文

Liu et al. revealed that ERCC6L2 is a DNA double strand break repair factor that both enhances the efficiency of immunoglobulin gene class switch recombination and dictates the proper orientation of end joining. ERCC6L2 rapidly localizes to DNA breaks and is necessary for efficient recruitment of other repair factors, suggesting an integral and early role in the complex process that allows for the expression of antibodies with different effector functions.

Keyword:

DNA-REPAIR

AI总结

对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。

期刊

Cell Research

IF:

25.9

论文数:

3.8K

被引数:

2.9W

机构

Yale University

学者数:

1.0K

论文数: 409

被引数: 0

引用论文

ERCC6L2 promotes DNA orientation-specific recombination in mammalian cells

CELL RESEARCH

IF25.9

2020-04-30

OAAI

Liu, Xiaojing; Liu, Tingting; Shang, Yafang; Dai, Pengfei; Zhang, Wubing; Lee, Brian J.; Huang, Min; Yang, Dingpeng; Wu, Qiu; Liu, Liu Daisy; Zheng, Xiaoqi; Zhou, Bo O.; Dong, Junchao; Yeap, Leng-Siew; Hu, Jiazhi; Xiao, Tengfei; Zha, Shan; Casellas, Rafael; Liu, X. Shirley; Meng, Fei-Long

S-S Synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase 类转换重组过程中的s-s突触由位于远处的转录元件和激活诱导的脱氨酶促进

IMMUNITY

IF26.3

2007-11-01

201

OAAI

Wuerffe, Robert; Wang, Lili; Grigera, Fernando; Manis, John; Selsing, Erik; Perlot, Thomas; Alt, Frederick W.; Cogne, Michel; Pinaud, Eric; Kenter, Amy L.

Feedback actions of locomotor activity to the circadian clock

Progress in Brain Research

IF0

2012-01-01

PREAI

Alun T.L. Hughes; Hugh D. Piggins

MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining

MOLECULAR CELL

IF16.6

2018-07-01

OAAI

Hung, Putzer J.; Johnson, Britney; Chen, Bo-Ruei; Byrum, Andrea K.; Bredemeyer, Andrea L.; Yewdell, William T.; Johnson, Tanya E.; Lee, Brian J.; Deivasigamani, Shruthi; Hindi, Issa; Amatya, Parmeshwar; Gross, Michael L.; Paull, Tanya T.; Pisapia, David J.; Chaudhuri, Jayanta; Petrini, John J. H.; Mosammaparast, Nima; Amarasinghe, Gaya K.; Zha, Shan; Tyler, Jessica K.; Sleckman, Barry P.

Clinicopathologic Features of Severe Acute Hepatitis Associated With Adenovirus Infection in Children

American Journal of Surgical Pathology

IF0

2023-06-26

PREAI

Jiancong Liang; David R. Kelly; Anita Pai; Lynette A. Gillis; Luz Helena Gutierrez Sanchez; Henry H. Shiau; Huiying Wang; Hernan Correa; Saeed Mohammad; Kay Washington

Effect of low-dose dopamine therapy on catecholamine values in cerebrospinal fluid in preterm neonates

The Journal of Pediatrics

IF0

1984-09-01

PREAI

I. Seri; T. Tulassay; J. Kiszel; E. Sulyok; T. Ertl; J. Bódis; S. Csömör

DNA double-strand break response factors influence end-joining features of IgH class switch and general translocation junctions

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2018-01-08

OAAI

Panchaksharia, Rohit A.; Zhang, Xuefei; Kumar, Vipul; Du, Zhou; Wei, Pei-Chi; Kao, Jennifer; Dong, Junchao; Alt, Frederick W.

A Damage-Independent Role for 53BP1 that Impacts Break Order and Igh Architecture during Class Switch Recombination

CELL REPORTS

IF6.9

2016-06-01

OAAI

Rocha, Pedro P.; Raviram, Ramya; Fu, Yi; Kim, JungHyun; Luo, Vincent M.; Aljoufi, Arafat; Swanzey, Emily; Pasquarella, Alessandra; Balestrini, Alessia; Miraldi, Emily R.; Bonneau, Richard; Petrini, John; Schotta, Gunnar; Skok, Jane A.

Low levels of Ypt protein prenylation cause vesicle polarization defects and thermosensitive growth that can be suppressed by genes involved in cell wall maintenance

Molecular Microbiology

IF0

2002-01-18

PREAI

Urszula Bialek‐Wyrzykowska; Bettina E. Bauer; Wolfgang Wagner; Sepp D. Kohlwein; Rudolf J. Schweyen; Antonella Ragnini

ERCC6L2 Mutations Link a Distinct Bone-Marrow-Failure Syndrome to DNA Repair and Mitochondrial Function

AMERICAN JOURNAL OF HUMAN GENETICS

IF8.1

2014-02-01

OAAI

Tummala, Hemanth; Kirwan, Michael; Walne, Amanda J.; Hossain, Upal; Jackson, Nicholas; Pondarre, Corinne; Plagnol, Vincent; Vulliamy, Tom; Dokal, Inderjeet

查看更多内容