Mapping individual differences in intermodal coupling in neurodevelopment

Ruyi Pan

doi:10.1162/IMAG.a.156

2025-09-22

Aaron Alexander‐Bloch

Theodore D. Satterthwaite

Jun Young Park *

DOI：10.1162/IMAG.a.156

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个体内部脑结构与功能测量之间的耦合在发育过程中演变，并可能构成神经精神疾病不同风险的基础。尽管对结构与功能关系发育的研究兴趣日益增加，但量化并检验耦合个体差异的严谨方法仍处于起步阶段。本文探讨了检验和空间定位跨模态耦合个体差异的方法学差距，包括一种新方法，称为CEIDR（用于检验rho（r）个体差异的聚类增强方法）。CEIDR通过控制源自均值和方差异质性的跨模态相关性个体差异中的假阳性，并通过采用自适应聚类增强来提高统计效能。通过比较检验跨模态耦合个体差异的不同方法，我们阐明了它们所检验假设的细微差异，这最终可能导致研究者得出不同结果。最后，我们使用费城神经发育队列的数据，通过两项针对脑发育的应用来说明这些差异。

Keyword:

individual differences

coupling

neurodevelopment

multimodal neuroimaging

hypothesis testing

期刊

Imaging Neuroscience

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论文数:

290

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