.png){kind=icon}
返回
MCSS: microbial community simulator based on structure
.png){kind=icon}
OA
AI
DOI：10.3389/fmicb.2024.1358257.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
De novo assembly plays a pivotal role in metagenomic analysis, and the incorporation of third-generation sequencing technology can significantly improve the integrity and accuracy of assembly results. Recently, with advancements in sequencing technology (Hi-Fi, ultra-long), several long-read-based bioinformatic tools have been developed. However, the validation of the performance and reliability of these tools is a crucial concern. To address this gap, we present MCSS (microbial community simulator based on structure), which has the capability to generate simulated microbial community and sequencing datasets based on the structure attributes of real microbiome communities. The evaluation results indicate that it can generate simulated communities that exhibit both diversity and similarity to actual community structures. Additionally, MCSS generates synthetic PacBio Hi-Fi and Oxford Nanopore Technologies (ONT) long reads for the species within the simulated community. This innovative tool provides a valuable resource for benchmarking and refining metagenomic analysis methods.Code available at: https://github.com/panlab-bio/mcss
Keyword:
metagenome
microbiome communities
long reads
simulator
assembly
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
4.5
论文数:
4.0W
被引数:
16.6W
机构
引用论文
Nanopore sequencing technology, bioinformatics and applications纳米孔测序技术、生物信息学及应用.png)
NATURE BIOTECHNOLOGY
OAAI
NATURE BIOTECHNOLOGYIF41.7
OAAI分享收藏Characterization and simulation of metagenomic nanopore sequencing data with Meta-NanoSim基于meta-nanosim的宏基因组纳米孔测序数据的表征和模拟GIGASCIENCEOAAI
GIGASCIENCEIF3.9
OAAI分享收藏Generating lineage-resolved, complete metagenome-assembled genomes from complex microbial communities从复杂的微生物群落中生成谱系解析的完整宏基因组组装的基因组NATURE BIOTECHNOLOGY
NATURE BIOTECHNOLOGYIF41.7
PREAI
分享收藏Understanding the microbial basis of body odor in pre-pubescent children and teenagersMICROBIOMEOAAI
MICROBIOMEIF12.7
OAAI分享收藏
查看更多内容