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Measuring and manipulating mechanical forces during development

delete2025-03-10
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DOI:10.1038/s41556-025-01632-xdelete
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摘要

摘要

En 中文
组织变形是发育的核心特征,从早期胚胎发育、生长和构建躯体蓝图到功能性器官的建立。这些变形通常由细胞及细胞群体产生的主动收缩力引起,并通过其力学性质的变化介导。力学力驱动功能性器官结构的形成,但也协调细胞行为和命运转变,确保发育的稳健性。显微镜、遗传学和化学领域的进步使测量、产生和扰动力学力的工具日益强大。本文讨论了测量和操纵力学力的方法,重点聚焦于发育过程,范围从分子相互作用的量化到组织力学性质的映射。我们着重于当代方法,并讨论这些方法所促进的生物发现。最后,我们展望了物理学、化学和生物学交叉领域的方法学,以构建对组织形态动力学整合理解。
Keyword:
EXTRACELLULAR-MATRIX
IN-VIVO
CORTICAL FORCES
CELL
TISSUE
TENSION
MORPHOGENESIS
FLOW
COHERENCE
REVEALS

期刊

Nature Cell Biology 封面图
Nature Cell Biology
IF:
19.1
论文数:
6.2K
被引数:
4.8W

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