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Mechanosensitive bonds induced complex cell motility patterns
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DOI：10.1103/PhysRevResearch.6.013164.png)
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The one-dimensional crawling movement of a cell is considered in this theoretical study. Our active gel model shows that a moving cell with weakly mechanosensitive adhesion complexes tends to move at constant velocity. As the mechanosensitivity of the adhesion complexes increases, a cell with sufficiently strong myosin contractile or high actin polymerization rate can exhibit stick-slip motion. Finally, a cell with highly mechanosensitive adhesion complexes exhibits periodic back-and-forth migration. A simplified model that assumes that the cell crawling dynamics are controlled by the evolution of the myosin density dipole and the asymmetry of adhesion complex distribution captures the motility behaviors of crawling cells qualitatively. It suggests that complex cell crawling behaviors could result from the interplay between the distribution of contractile force and mechanosensitive bonds.
Keyword:
ACTIN-FILAMENTS
FOCAL ADHESIONS
MYOSIN-II
REORGANIZATION
POLARITY
MODEL
REAR
期刊
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4.2
论文数:
7.6K
被引数:
2.7W
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Understanding the Cooperative Interaction between Myosin II and Actin Cross-Linkers Mediated by Actin Filaments during Mechanosensation.png)
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