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Micro-elastometry on whole blood clots using actuated surface-attached posts (ASAPs)
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DOI：10.1039/c4lc01478b.png)
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摘要
En 中文
We present a novel technology for microfluidic elastometry and demonstrate its ability to measure stiffness of blood clots as they form. A disposable micro-capillary strip draws small volumes (20 mu L) of whole blood into a chamber containing a surface-mounted micropost array. The posts are magnetically actuated, thereby applying a shear stress to the blood clot. The posts' response to magnetic field changes as the blood clot forms; this response is measured by optical transmission. We show that a quasi-static model correctly predicts the torque applied to the microposts. We experimentally validate the ability of the system to measure clot stiffness by correlating our system with a commercial thromboelastograph. We conclude that actuated surface-attached post (ASAP) technology addresses a clinical need for point-of-care and small-volume elastic haemostatic assays.
Keyword:
CARDIAC-SURGERY
THROMBELASTOGRAPHY
TRAUMA
FORCE
RESUSCITATION
MICRORHEOLOGY
COAGULOPATHY
TRANSFUSION
MANAGEMENT
VISCOSITY
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5.4
论文数:
9.0K
被引数:
3.3W
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