.png){kind=icon}
返回
miR-124 dosage regulates prefrontal cortex function by dopaminergic modulation
.png){kind=icon}
OA
AI
DOI：10.1038/s41598-019-38910-2.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
MicroRNA-124 (miR-124) is evolutionarily highly conserved among species and one of the most abundantly expressed miRNAs in the developing and mature central nervous system (CNS). Previous studies reported that miR-124 plays a role in CNS development, such as neuronal differentiation, maturation, and survival. However, the role of miR-124 in normal brain function has not yet been revealed. Here, we subjected miR-124-1(+/- )mice, to a comprehensive behavioral battery. We found that miR-124-1(+/-) mice showed impaired prepulse inhibition (PPI), methamphetamine-induced hyperactivity, and social deficits. Whole cell recordings using prefrontal cortex (PFC) slices showed enhanced synaptic transmission in layer 5 pyramidal cells in the miR-124-1(+/-) PFC. Based on the results of behavioral and electrophysiological analysis, we focused on genes involved in the dopaminergic system and identified a significant increase of Drd2 expression level in the miR-124-1(+/-) PFC. Overexpression or knockdown of Drd2 in the control or miR-124-1(+/-) PFC demonstrates that aberrant Drd2 signaling leads to impaired PPI. Furthermore, we identified that expression of glucocorticoid receptor gene Nr3c1, which enhances Drd2 expression, increased in the miR-124-1(+/-) PFC. Taken together, the current study suggests that miR-124 dosage modulates PFC function through repressing the Drd2 pathway, suggesting a critical role of miR-124 in normal PFC function.
Keyword:
PREPULSE INHIBITION
NERVOUS-SYSTEM
LATENT INHIBITION
GENE-EXPRESSION
MOTOR BEHAVIOR
SCHIZOPHRENIA
STRESS
MICRORNA-124
AMPHETAMINE
RECEPTORS
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
3.9
论文数:
28.0W
被引数:
83.5W
机构
引用论文
Characterization of Small RNAs in Aplysia Reveals a Role for miR-124 in Constraining Synaptic Plasticity through CREB.png)
NEURON
OAAI
NEURONIF15
OAAI分享收藏Genome-wide scan of homogeneous subtypes of NIMH genetics initiative schizophrenia familiesPSYCHIATRY RESEARCH
PSYCHIATRY RESEARCHIF3.9
PREAI
分享收藏Knockdown of DISC1 by In Utero Gene Transfer Disturbs Postnatal Dopaminergic Maturation in the Frontal Cortex and Leads to Adult Behavioral DeficitsNEURONOAAI
NEURONIF15
OAAI分享收藏The microRNA miR-124 controls gene expression in the sensory nervous system of Caenorhabditis elegansNUCLEIC ACIDS RESEARCHOAAI
NUCLEIC ACIDS RESEARCHIF13.1
OAAI分享收藏分享收藏Neurophysiological Defects and Neuronal Gene Deregulation in Drosophila mir-124 MutantsPLOS GENETICSOAAI
PLOS GENETICSIF3.7
OAAI分享收藏
查看更多内容