.png){kind=icon}
返回
Mitochondrial Dysfunction in CD4+T Effector Memory RA plus Cells
.png){kind=icon}
OA
AI
DOI：10.3390/biology12040597.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Simple Summary The mitochondria is the powerhouse of the cell. This powerhouse becomes somehow dysfunctional as we get older; hence, our immune responses to infection become poor, resulting in poor vaccine efficiency. This factor is essential when designing vaccines for the elderly. In this study, we aim to study the biology of specific immune cells and understand why and how they exhibit different mitochondrial phenomena and dynamics when confronted with stimulation following infection. Human ageing is accompanied by poor responses to infection and decreased vaccine efficacy. While the causes of this can be attributed to defects in the immune system that increase with age, it is unknown whether mitochondrial dysfunction may also contribute to these phenomena. This study aims to assess mitochondrial dysfunction in CD4+ terminal effector memory T cells re-expressing CD45RA (TEMRA) cells and other CD4+ memory T cell subtypes, which are increased in number in the elderly population, with respect to how their metabolic responses to stimulation are altered compared to CD4+ naive T cells. In this study, we show that CD4+ TEMRA cells exhibit altered mitochondrial dynamics compared to CD4+ naive cells and CD4+ central and effector memory cells, with a 25% reduction in OPA1 expression. CD4+ TEMRA and memory cells show increased upregulation of Glucose transporter 1 following stimulation and higher levels of mitochondrial mass compared to CD4+ naive T cells. Additionally, TEMRA cells exhibit a decrease in mitochondrial membrane potential compared to other CD4+ memory cell subsets by up to 50%. By comparing young to aged individuals, more significant mitochondria mass and lower membrane potential were observed in CD4+ TEMRA of young individuals. In conclusion, we suggest that CD4+ TEMRA cells may be impaired with respect to their metabolic response to stimulation, possibly contributing to impaired responses to infection and vaccination.
Keyword:
metabolism(1)
T cells
terminally differentiated effector memory T cells (TEMRA)
stimulation
flow cytometry
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
3.5
论文数:
7.1K
被引数:
2.3W
机构
引用论文
Mitochondrial mass governs the extent of human T cell senescence线粒体质量控制人类T细胞衰老的程度.png)
AGING CELLOAAI
AGING CELLIF7.1
OAAI分享收藏Unique phenotypes and clonal expansions of human CD4 effector memory T cells re-expressing CD45RANATURE COMMUNICATIONSOAAI
NATURE COMMUNICATIONSIF15.7
OAAI分享收藏Mitochondrial Ca2+ and membrane potential, an alternative pathway for Interleukin 6 to regulate CD4 cell effector functionELIFEOAAI
ELIFEIF0
OAAI分享收藏p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cellsp38信号抑制人衰老CD8 T细胞的mTORC1-independent自噬
OAAI
OAAI分享收藏分享收藏分享收藏
查看更多内容