Mobile integrons encode phage defense systems

doi:10.1126/science.ads0915

2025-05-08

PRE

Nicolas Kieffer

Alberto Hipólito

Laura Ortiz-Miravalles

Meritxell García‐Quintanilla

André Carvalho

Pilar Domingo‐Calap

José Antonio Escudero *

DOI：10.1126/science.ads0915

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整合子是细菌遗传元件，能够捕获、储存并调控整合子 cassette 中编码的基因的表达。移动整合子（MIs）存在于质粒上，作为关键病原体之间数百种抗菌耐药基因的载体。这些元件还携带功能未知的基因 cassette（gcus），其作用和适应性价值尚待探索。在本研究中，我们证明 gcus 编码噬菌体抗性系统，其中许多是 newly discovered 的。噬菌体抗性整合子 cassette（BRiCs）可以与耐药 cassette 组合和混合，产生多噬菌体或药物与噬菌体联合抗性。BRiCs 的适应成本具有可变性，取决于遗传背景，并且可以通过改变 cassette 数组的顺序来调控。因此，MIs 作为高度移动、低成本的防御岛发挥作用。

Keyword:

IMMUNE-SYSTEMS

GENE CASSETTES

BACTERIAL

SITE

ADAPTATION

DIVERSITY

EVOLUTION

FEATURES

ISLANDS

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Science

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univ valencia csic

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Fdn Jimenez Diaz

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