Modeling human mutations to understand TRIO GEF function during development

Erin Fingleton

doi:10.1016/j.tins.2023.03.004

2023-06-01

Erin Fingleton

Katherine W. Roche *

DOI：10.1016/j.tins.2023.03.004

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摘要

En 中文

In a recent study, Bonnet and colleagues leveraged in silico structure prediction and human genetic data to understand the molecular regulation of the Rac1-activating guanie nucleotide exchange factor (Rac1-GEF) domain of Trio. Their work sheds new light on the role of Trio during axon guidance and explores the mechanism by which Trio GEF function is regulated in health and dysregulated in disease.

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期刊

Trends in Neurosciences

IF:

15.1

论文数:

5.3K

被引数:

2.2W

机构

national institutes of health (nih) - usa

学者数:

10.3W

论文数: 8.2W

被引数: 111

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