.png){kind=icon}
返回
Monte Carlo Null Models for Genomic Data
.png){kind=icon}
OA
AI
DOI：10.1214/14-STS484.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
As increasingly complex hypothesis-testing scenarios are considered in many scientific fields, analytic derivation of null distributions is often out of reach. To the rescue comes Monte Carlo testing, which may appear deceptively simple: as long as you can sample test statistics under the null hypothesis, the p-value is just the proportion of sampled test statistics that exceed the observed test statistic. Sampling test statistics is often simple once you have a Monte Carlo null model for your data, and defining some form of randomization procedure is also, in many cases, relatively straightforward. However, there may be several possible choices of a randomization null model for the data and no clear-cut criteria for choosing among them. Obviously, different null models may lead to very different p-values, and a very low p-value may thus occur due to the inadequacy of the chosen null model. It is preferable to use assumptions about the underlying random data generation process to guide selection of a null model. In many cases, we may order the null models by increasing preservation of the data characteristics, and we argue in this paper that this ordering in most cases gives increasing p-values, that is, lower significance. We denote this as the null complexity principle. The principle gives a better understanding of the different null models and may guide in the choice between the different models.
Keyword:
Monte Carlo methods
hypothesis testing
genomics
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
3.4
论文数:
1.0K
被引数:
8.7K
机构
引用论文
Polypyrimidine Tract Binding Protein-1 (PTB1) Is a Determinant of the Tissue and Host Tropism of a Human Rhinovirus/Poliovirus Chimera PV1(RIPO).png)
PLoS ONEOAAI
PLoS ONEIF0
OAAI分享收藏Combinatorial patterns of histone acetylations and methylations in the human genomeNATURE GENETICSOAAI
NATURE GENETICSIF31.8
OAAI分享收藏Altered Spontaneous Brain Activity in Patients with Parkinson’s Disease Accompanied by Depressive Symptoms, as Revealed by Regional Homogeneity and Functional Connectivity in the Prefrontal-Limbic SystemPLoS ONEOAAI
PLoS ONEIF0
OAAI分享收藏Large-scale analysis of the regulatory architecture of the mouse genome with a transposon-associated sensorNATURE GENETICS
NATURE GENETICSIF31.8
PREAI
分享收藏分享收藏
查看更多内容