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Multidimensional proteomics for cell biology
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DOI：10.1038/nrm3970.png)
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摘要
En 中文
The proteome is a dynamic system in which each protein has interconnected properties-dimensions-that together contribute to the phenotype of a cell. Measuring these properties has proved challenging owing to their diversity and dynamic nature. Advances in mass spectrometry-based proteomics now enable the measurement of multiple properties for thousands of proteins, including their abundance, isoform expression, turnover rate, subcellular localization, post-translational modifications and interactions. Complementing these experimental developments are new data analysis, integration and visualization tools as well as data-sharing resources. Together, these advances in the multidimensional analysis of the proteome are transforming our understanding of various cellular and physiological processes.
Keyword:
HYDROPHILIC-INTERACTION CHROMATOGRAPHY
SPECTROMETRY-BASED PROTEOMICS
MASS-SPECTROMETRY
PROTEIN COMPLEXES
QUANTITATIVE PROTEOMICS
SACCHAROMYCES-CEREVISIAE
SYSTEMATIC ANALYSIS
CROSS-LINKING
IDENTIFICATION
PHOSPHORYLATION
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