MYC: a complex problem

Subhendu Das

doi:10.1016/j.tcb.2022.07.006

2023-03-01

Subhendu Das

Brian A. Lewis

Levens, David *

DOI：10.1016/j.tcb.2022.07.006

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摘要

En 中文

The MYC protooncogene functions as a universal amplifier of transcription through interaction with numerous factors and complexes that regulate almost every cellular process. However, a comprehensive model that explains MYC's actions and the interplay governing the complicated dynamics of components of the transcription and replication machinery is still lacking. Here, we review the potency of MYC as an oncogenic driver and how it regulates the broad spec-trum of complexes (effectors and regulators). We propose a 'hand-over model' for differential partitioning and trafficking of unstructured MYC via a loose interaction network between various gene-regulatory complexes and factors. Additionally, the article discusses how unstructured-MYC energetically favors efficient modulation of the energy landscape of the transcription cycle.

Keyword:

RNA-POLYMERASE-II

C-MYC

N-MYC

EMBRYONIC LETHALITY

TRANSCRIPTIONAL ACTIVATION

HISTONE ACETYLTRANSFERASE

NUCLEOTIDE-SEQUENCES

PROTEIN STABILITY

DNA-REPLICATION

GENE-REGULATION

期刊

Trends in Cell Biology

IF:

18.1

论文数:

3.1K

被引数:

2.0W

机构

national institutes of health (nih) - usa

学者数:

10.3W

论文数: 8.2W

被引数: 111

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