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N6-methyladenosine-encoded epitranscriptomics
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DOI：10.1038/nsmb.3162.png)
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摘要
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N-6-methyladenosine (m(6)A) is the most abundant internal modification in eukaryotic mRNA. Recent discoveries of the locations, functions and mechanisms of m(6)A have shed light on a new layer of gene regulation at the RNA level, giving rise to the field of m(6)A epitranscriptomics. In this Perspective, we provide an update on the various effects of mammalian m(6)A modification, which affects many different stages of the RNA life cycle.
Keyword:
MESSENGER-RNA METHYLATION
SINGLE-NUCLEOTIDE-RESOLUTION
M(6)A RNA
NUCLEAR-RNA
HNRNP C
SEQUENCE SPECIFICITY
MAPPING REVEALS
POLYMERASE-II
YTH DOMAIN
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10.1
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分享收藏分享收藏分享收藏Molecular basis for the recognition of methylated adenines in RNA by the eukaryotic YTH domain真核YTH结构域识别RNA中甲基化腺嘌呤的分子基础
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OAAI分享收藏The thermodynamic stability of RNA duplexes and hairpins containing N6-alkyladenosines and 2-methylthio-N6-alkyladenosines.png)
NUCLEIC ACIDS RESEARCHOAAI
NUCLEIC ACIDS RESEARCHIF13.1
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