.png){kind=icon}
返回
Nascent polypeptide sequences that influence ribosome function
.png){kind=icon}
PRE
AI
DOI：10.1016/j.mib.2011.01.011.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Ribosomes catalyze protein synthesis using transfer RNAs and auxiliary proteins. Historically, ribosomes have been considered nonspecific translational machines, having no regulatory functions. However, a new class of regulatory mechanisms has been discovered that is based on interactions occurring within the ribosomal peptide exit tunnel that result in ribosome stalling during translation of an appropriate mRNA segment. These discoveries reveal an unexpectedly dynamic role ribosomes play in regulating their own activity. By using nascent leader peptides in combination with bound specific amino acids or antibiotics, ribosome functions can be altered significantly resulting in regulated expression of downstream coding regions. This review summarizes relevant findings in recent articles and outlines our current understanding of nascent peptide-induced ribosome stalling in regulating gene expression.
Keyword:
PEPTIDYL TRANSFERASE CENTER
TRYPTOPHANASE OPERON EXPRESSION
ARGININE ATTENUATOR PEPTIDE
ESCHERICHIA-COLI K-12
OPEN READING FRAME
EXIT TUNNEL
TRANSLATION ARREST
TRANSFER-RNA
IN-VITRO
ANGSTROM RESOLUTION
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
7.5
论文数:
3.1K
被引数:
1.3W
机构
引用论文
Coronary heart disease, hypertension and use of biomass fuel among women: comparative cross-sectional study.png)
BMJ Open
OAAI
BMJ OpenIF0
OAAI分享收藏The key function of a conserved and modified rRNA residue in the ribosomal response to the nascent peptide保守和修饰的rRNA残基在核糖体对新生肽的反应中的关键功能EMBO JOURNALOAAI
EMBO JOURNALIF8.3
OAAI分享收藏Features of ribosome-peptidyl-tRNA interactions essential for tryptophan induction of tna operon expressionMOLECULAR CELLOAAI
MOLECULAR CELLIF16.6
OAAI分享收藏
查看更多内容