.png){kind=icon}
返回
Network cloning using DNA barcodes
.png){kind=icon}
OA
AI
DOI：10.1073/pnas.1706012116.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
The connections between neurons determine the computations performed by both artificial and biological neural networks. Recently, we have proposed SYNSeq, a method for converting the connectivity of a biological network into a form that can exploit the tremendous efficiencies of high-throughput DNA sequencing. In SYNSeq, each neuron is tagged with a random sequence of DNA-a barcodeand synapses are represented as barcode pairs. SYNSeq addresses the analysis problem, reducing a network into a suspension of barcode pairs. Here, we formulate a complementary synthesis problem: How can the suspension of barcode pairs be used to clone or copy the network back into an uninitialized tabula rasa network? Although this synthesis problem might be expected to be computationally intractable, we find that, surprisingly, this problem can be solved efficiently, using only neuron-local information. We present the one-barcode-one-cell (OBOC) algorithm, which forces all barcodes of a given sequence to coalesce into the same neuron, and show that it converges in a number of steps that is a power law of the network size. Rapid and reliable network cloning with single-synapse precision is thus theoretically possible.
Keyword:
neural networks
connectomics
DNA barcodes
neural development
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
P
IF:
9.1
论文数:
10.8W
被引数:
73.5W
机构
引用论文
High-Throughput Mapping of Single-Neuron Projections by Sequencing of Barcoded RNA通过条形码RNA的测序对单神经元投影进行高通量映射.png)
NEURONOAAI
NEURONIF15
OAAI分享收藏分享收藏High-precision automated reconstruction of neurons with flood-filling networksNATURE METHODSOAAI
NATURE METHODSIF32.1
OAAI分享收藏Learning a music similarity measure on automatic annotations with application to playlist generation
PREAI
分享收藏Variability in Institutional Screening Practices Related to Collegiate Student-Athlete Mental HealthOAAI
OAAI分享收藏HSAB Analysis of Charge Transfer in the Gas-Phase Acid−Base Equilibria of Alkyl-Substituted Alcohols
PREAI
分享收藏
查看更多内容