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New insights into E-protein function in lymphocyte development
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DOI：10.1016/j.it.2005.03.011.png)
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Lymphocyte development has long served as an experimental paradigm, revealing fundamental mechanisms of gene regulation and cellular differentiation in mammals. The study of E-protein-mediated transcriptional regulation in lymphocyte development provides a means to address these mechanistic issues. Both genetic and biochemical studies have defined many important regulatory events during lymphocyte development that are mediated by E-proteins. The E2A gene, one of the three known E-protein genes in mammals, has a particularly important role in B-lymphocyte development. Major progress has been made in recent years towards understanding the physiological targets of E2A during B-lymphocyte development. Most notably, new insights have been gained regarding the role of E2A in controlling lineage commitment and V(D)J recombination. This Review focuses primarily on E2A-mediated gene regulation during B-lymphocyte development.
Keyword:
B-CELL DEVELOPMENT
LOOP-HELIX PROTEINS
CHAIN INTRONIC ENHANCER
IMMUNOGLOBULIN ENHANCER
TRANSCRIPTION FACTORS
DNA-BINDING
T-CELL
SIGNALING PATHWAY
GENE-EXPRESSION
HLH PROTEINS
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