Adam S. Lazorchak - Publications, H-index & Citations

Adam S. Lazorchak

be biopharma

17H指数

59论文数

1.8K被引数

收录论文 16

发表时间

A Precision Gene Engineered B Cell Medicine Producing Sustained Levels of Active Factor IX for Hemophilia B Therapy 一种精确基因工程B细胞药物，可持续产生活性因子IX，用于血友病B的治疗

Molecular Therapy

IF12

2025-09-05

OAAI

Hanlan Liu; Swati Singh; Timothy J. Mullen; Caroline Bullock; Sean Keegan; Troy Patterson; Sakshisingh Thakur; Amy Lundberg; Sol Shenker; Ryan Couto; Charuta Yadav; Shamael Dastagir; Lily Li; Wayne Bainter; Ella Liberzon; Connor R. Malloy; Cicera R. Lazzarotto; Toshiro K. Ohsumi; Shalini Chilakala; Huei-Mei Chen; Rashmi Kshirsagar; Anja F. Hohmann; Sean Arlauckas; Adam Lazorchak; Chris Scull; Richard A. Morgan

Development of an ex vivo precision gene engineered B cell medicine that produces highly active and sustained levels of acid sphingomyelinase for the treatment of Neimann-Pick disease

MOLECULAR GENETICS AND METABOLISM

IF3.5

2024-02-01

PREAI

Musial-Siwek, Monika; Datta, Ishara; Bainter, Wayne; Mullen, Timothy; Malloy, Connor; Leiken, Michael; Lundberg, Amy; Leach, Sarah; Brophy, Megan; Hohmann, Anja; Arlauckas, Sean; Lazorchak, Adam; Fiorini, Claudia; Liu, Hanlan; Morgan, Richard A.

E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin κ locus in pre-B cells

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Lazorchak, AS; Schlissel, MS; Zhuang, Y

Colocalized targeting of TGF-β and PD-L1 by bintrafusp alfa elicits distinct antitumor responses

JOURNAL FOR IMMUNOTHERAPY OF CANCER

IF10.6

2022-07-20

OAAI

Lan, Yan; Yeung, Tsz-Lun; Huang, Hui; Wegener, Ansgar A.; Saha, Somdutta; Toister-Achituv, Mira; Jenkins, Molly H.; Chiu, Li-Ya; Lazorchak, Adam; Tarcic, Ohad; Wang, Hong; Qi, Jin; Locke, George; Kalimi, Doron; Qin, Guozhong; Marelli, Bo; Yu, Huakui; Gross, Alec W.; Derner, Melissa G.; Soloviev, Maria; Botte, Mathieu; Sircar, Aroop; Ma, Hong; Sood, Vanita D.; Zhang, Dong; Jiang, Feng; Lo, Kin-Ming

Human ESC-Derived MSCs Outperform Bone Marrow MSCs in the Treatment of an EAE Model of Multiple Sclerosis (vol 3, pg 115, 2014)

STEM CELL REPORTS

IF5.1

2021-02-01

OAAI

Wang, Xiaofang; Kimbrel, Erin A.; Ijichi, Kumiko; Paul, Debayon; Lazorchak, Adam S.; Chu, Jianlin; Kouris, Nicholas A.; Yavanian, Gregory J.; Lu, Shi-Jiang; Pachter, Joel S.; Crocker, Stephen J.; Lanza, Robert; Xu, Ren-He

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis (vol 15, pg 1340, 2013)

NATURE CELL BIOLOGY

IF19.1

2019-02-19

OAAI

Liu, Pengda; Gan, Wenjian; Inuzuka, Hiroyuki; Lazorchak, Adam S.; Gao, Daming; Arojo, Omotooke; Liu, Dou; Wan, Lixin; Zhai, Bo; Yu, Yonghao; Yuan, Min; Kim, Byeong Mo; Shaik, Shavali; Menon, Suchithra; Gygi, Steven P.; Lee, Tae Ho; Asara, John M.; Manning, Brendan D.; Blenis, John; Su, Bing; Wei, Wenyi

Immune Modulatory Mesenchymal Stem Cells Derived from Human Embryonic Stem Cells Through a Trophoblast-Like Stage 通过滋养层样阶段衍生自人胚胎干细胞的免疫调节性间充质干细胞

Stem Cells

IF3.6

2015-11-28

OAAI

Wang, Xiaofang; Lazorchak, Adam S.; Song, Li; Li, Enqin; Zhang, Zhenwu; Jiang, Bin; Xu, Ren-He

Human ESC-Derived MSCs Outperform Bone Marrow MSCs in the Treatment of an EAE Model of Multiple Sclerosis

STEM CELL REPORTS

IF5.1

2014-07-01

132

OAAI

Sinl phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

NATURE CELL BIOLOGY

IF19.1

2013-10-27

233

OAAI

Perspectives on the role of mTORC2 in B lymphocyte development, immunity and tumorigenesis

PROTEIN & CELL

IF12.8

2011-08-06

OAAI

Lazorchak, Adam S.; Su, Bing

mTOR Complex 2 Targets Akt for Proteasomal Degradation via Phosphorylation at the Hydrophobic Motif

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2011-04-01

OAAI

Wu, You-Tong; Ouyang, Weiming; Lazorchak, Adam S.; Liu, Dou; Shen, Han-Ming; Su, Bing

Sin1-mTORC2 Suppresses rag and il7r Gene Expression through Akt2 in B Cells

MOLECULAR CELL

IF16.6

2010-08-01

OAAI

Lazorchak, Adam S.; Liu, Dou; Facchinetti, Valeria; Di Lorenzo, Annarita; Sessa, William C.; Schatz, David G.; Su, Bing

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C 雷帕霉素复合物2的哺乳动物靶标控制Akt和蛋白激酶C的折叠和稳定性

EMBO JOURNAL

IF8.3

2008-06-19

514

OAAI

Facchinetti, Valeria; Ouyang, Weiming; Wei, Hua; Soto, Nelyn; Lazorchak, Adam; Gould, Christine; Lowry, Carolyn; Newton, Alexandra C.; Mao, Yuxin; Miao, Robert Q.; Sessa, William C.; Qin, Jun; Zhang, Pumin; Su, Bing; Jacinto, Estela

E2A promotes the survival of precursor and mature B lymphocytes

JOURNAL OF IMMUNOLOGY

IF3.4

2006-08-15

OAAI

Lazorchak, Adam S.; Wojciechowski, Jason; Dai, Meifang; Zhuang, Yuan

New insights into E-protein function in lymphocyte development

TRENDS IN IMMUNOLOGY

IF13.9

2005-06-01

PREAI

Lazorchak, A; Jones, ME; Zhuang, Y