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Olive leaf protein hydrolysates yield gastro-resistant peptides with antioxidant and anti-inflammatory potential: peptidomics, in vitro validation and molecular docking analyses

delete2026-08-01
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OA
AI
T
Teresa Gonzalez‐de la Rosa
A
Alonso Herreros-Isidro
L
Luna Barrera‐Chamorro
M
Maria Torrecillas-Lopez
F
Fernando Rivero‐Pino
C
Carmen Claro-Cala
S
Sergio Montserrat-de la Paz *
DOI:10.1016/j.foodres.2026.120220delete
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Abstract

Abstract

En 中文
• Ultrasound–alkaline extraction enriched olive-leaf proteins from by-products. • Enzymatic hydrolysis improved DPPH activity; OLPH15A chosen for scaling. • dOLPH15A reduced LPS inflammation and enhanced barrier genes in Caco-2. • Peptidomics revealed digestion resistant low-mass peptides after INFOGEST. • Docking found four peptides binding TLR4/MD2, supporting immunomodulation.
Keywords:
Olea europaea
Bioactive peptides
Protein hydrolysates
Antioxidant activity
Anti-inflammatory activity
Molecular docking
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Journal

Food Research International cover
Food Research International
IF:
8
Papers:
1.7W
Citations:
7.9W

Organization

U
university of seville
Scholars:
472
Papers: 205
Citations: 0
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