.png){kind=icon}
返回
Optical-Switch Raman Spectroscopy for High Throughput Screening
.png){kind=icon}
OA
AI
DOI：10.1007/s13206-023-00113-3.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Although surface-enhanced Raman spectroscopy (SERS) is a powerful analytical technique with unbeaten sensitivity, the capabilities of SERS have been not fully utilized in screening applications because throughput of spectrum detection by conventional Raman instruments has been restricted due to their single-point measurement manners. Hence, this paper presents a development of a high throughput Raman screening system that employs a fiber-optic switch and a Raman probe array. In the system, a 785 nm excitation light is directed into the 1 x 8 broadband optical switching device and selectively switched to one of 8 output ports connected to the corresponding Raman probe array to deliver the light to samples under each probe. This optical switching driven probing in sequence allows us to rapidly detect Raman scattering of the multiple (n = 8) samples in array within a short time (similar to 28 s) with decent sensitivity (10(-7) M). The Raman spectroscopy of the system is validated by comparing the features of Raman spectra obtained from vitamin C tablets with those from a commercial Raman microscope and the detection sensitivity is measured with SERS substrates with different concentrations. Then, feasibility of high throughput screening is tested with a SERS chip array.
Keyword:
Raman spectroscopy
Surface enhanced Raman spectroscopy (SERS)
High throughput screening (HTS)
Multi-point measurement
Optical switch
期刊
IF:
6.1
论文数:
769
被引数:
1.4K
机构
引用论文
Evolving trends in SERS-based techniques for food quality and safety: A review基于SERS的食品质量和安全技术的发展趋势: 综述
PREAI
分享收藏DNA-Gold Nanoparticle Conjugates for Intracellular miRNA Detection Using Surface-Enhanced Raman Spectroscopy使用表面增强拉曼光谱检测细胞内miRNA的DNA-金纳米粒子缀合物.png)
BIOCHIP JOURNAL
BIOCHIP JOURNALIF6.1
PREAI
分享收藏分享收藏Development of a high throughput (HT) Raman spectroscopy method for rapid screening of liquid blood plasma from prostate cancer patients高通量 (HT) 拉曼光谱快速筛查前列腺癌患者血浆ANALYST
OAAI
ANALYSTIF3.3
OAAI分享收藏
查看更多内容