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Oxidation-responsive polymeric vesicles
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DOI：10.1038/nmat1081.png)
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Vesicles formed in water by synthetic macro-amphiphiles have attracted much attention as nanocontainers having properties that extend the physical and chemical limits of liposomes. We sought to develop ABA block copolymeric amphiphiles that self-assemble into unilamellar vesicles that can be further oxidatively destabilized. We selected poly(ethylene glycol) (PEG) as the hydrophilic A blocks, owing to its resistance to protein adsorption and low toxicity. As hydrophobic B blocks, we selected poly(propylene sulphide) (PPS), owing to its extreme hydrophobicity, its low glass-transition temperature, and most importantly its oxidative conversion from a hydrophobe to a hydrophile, poly(propylene sulphoxide) and ultimately poly(propylene sulphone). This is the first example of the use of oxidative conversions to destabilize such carriers. This new class of oxidation-responsive polymeric vesicles may find applications as nanocontainers in drug delivery, biosensing and biodetection.
Keyword:
TRANSMISSION ELECTRON-MICROSCOPY
STUDYING TRANSLATIONAL DIFFUSION
NUCLEAR-MAGNETIC-RESONANCE
BLOCK-COPOLYMERS
POLY(PROPYLENE SULFIDE)
POLY(ETHYLENE GLYCOL)
DIBLOCK COPOLYMERS
TRIBLOCK COPOLYMER
STABILITY
BEHAVIOR
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38.5
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6.8K
被引数:
11.5W
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