Oxidation-sensitive polymeric nanoparticles

Annemie Rehor

doi:10.1021/la0478043

2004-12-02

157

PRE

Annemie Rehor

Jeffrey A. Hubbell

Nicola Tirelli

DOI：10.1021/la0478043

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摘要

En 中文

We have recently demonstrated the possible use of organic polysulfides for the design of oxidation-sensitive colloidal carriers in the form of polymeric vesicles, which are particularly suitable for the encapsulation of hydrosoluble drugs. In the present research we extend our efforts to carriers specifically suitable for hydrophobic molecules. Exploiting the living emulsion polymerization of episulfides, we have produced new cross-linked polysulfide nanoparticles. Here we demonstrate how this process allows the production of stable nanoparticles with a good control over their size and functionality. The nanoparticles showed negligible cytotoxicity on a fibroblast model; furthermore, they exhibited sensitivity to oxidative conditions, which first produce swelling and then solubilize the material.

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COPOLYMERS

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Langmuir

IF:

3.9

论文数:

5.4W

被引数:

10.6W

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