.png){kind=icon}
返回
PADRE: Pedigree-Aware Distant-Relationship Estimation
.png){kind=icon}
OA
AI
DOI：10.1016/j.ajhg.2016.05.020.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Accurate estimation of shared ancestry is an important component of many genetic studies; current prediction tools accurately estimate pairwise genetic relationships up to the ninth degree. Pedigree-aware distant-relationship estimation (PADRE) combines relationship likelihoods generated by estimation of recent shared ancestry (ERSA) with likelihoods from family networks reconstructed by pedigree reconstruction and identification of a maximum unrelated set (PRIMUS), improving the power to detect distant relationships between pedigrees. Using PADRE, we estimated relationships from simulated pedigrees and three extended pedigrees, correctly predicting 20% more fourth-through ninth-degree simulated relationships than when using ERSA alone. By leveraging pedigree information, PADRE can even identify genealogical relationships between individuals who are genetically unrelated. For example, although 95% of 13th-degree relatives are genetically unrelated, in simulations, PADRE correctly predicted 50% of 13th-degree relationships to within one degree of relatedness. The improvement in prediction accuracy was consistent between simulated and actual pedigrees. We also applied PADRE to the HapMap3 CEU samples and report new cryptic relationships and validation of previously described relationships between families. PADRE greatly expands the range of relationships that can be estimated by using genetic data in pedigrees.
Keyword:
WHOLE-GENOME ASSOCIATION
DNA SAMPLES
RARE
INFERENCE
IDENTITY
DESCENT
LINKAGE
FAMILY
HEALTH
COMMON
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
8.1
论文数:
7.2K
被引数:
3.7W
机构
引用论文
Genetic Identification of Missing Persons: DNA Analysis of Human Remains and Compromised Samples.png)
PATHOBIOLOGY
PATHOBIOLOGYIF2
PREAI
分享收藏A General Approach for Haplotype Phasing across the Full Spectrum of RelatednessPLOS GENETICSOAAI
PLOS GENETICSIF3.7
OAAI分享收藏Detecting Rare Variant Associations by Identity-by-Descent Mapping in Case-Control StudiesGENETICSOAAI
GENETICSIF5.1
OAAI分享收藏
查看更多内容