.png){kind=icon}
返回
PAT implementation for advanced process control in solid dosage manufacturing-A practical guide
.png){kind=icon}
PRE
AI
DOI：10.1016/j.ijpharm.2021.121408.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
The implementation of continuous pharmaceutical manufacturing requires advanced control strategies rather than traditional end product testing or an operation within a small range of controlled parameters. A high level of automation based on process models and hierarchical control concepts is desired. The relevant tools that have been developed and successfully tested in academic and industrial environments in recent years are now ready for utilization on the commercial scale. To date, the focus in Process Analytical Technology (PAT) has mainly been on achieving process understanding and quality control with the ultimate goal of real-time release testing (RTRT). This work describes the workflow for the development of an in-line monitoring strategy to support PAT-based real-time control actions and its integration into solid dosage manufacturing. All stages are discussed in this paper, from process analysis and definition of the monitoring task to technology assessment and selection, its process integration and the development of data acquisition.
Keyword:
PAT
Advanced process control
Model predictive control
Continuous manufacturing
Control concept
期刊
IF:
5.2
论文数:
2.2W
被引数:
6.7W
机构
引用论文
Influence of water pH in oral changes caused by cadmium poisoning: an experimental study in rats
OAAI
OAAI分享收藏分享收藏分享收藏Calibration-free in-line monitoring of pellet coating processes via optical coherence tomography通过光学相干断层扫描对颗粒涂覆过程进行免校准在线监测
PREAI
分享收藏
Evaluation of the efficacy and safety of Ganoderma lucidum mycelium-fermented liquid on gut microbiota and its impact on cardiovascular risk factors in human.png)
RSC AdvancesOAAI
RSC AdvancesIF0
OAAI分享收藏
查看更多内容