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Organic Process Research and Development

IF3.5
论文数5846
被引数11313
期刊论文 5846
发表时间
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Some Items of Interest to Process R&D Chemists and Engineers对过程研究与开发化学家及工程师感兴趣的一些事项
deleteOrganic Process Research & Development
IF3.5
delete2025-12-09
delete0
deleteOAAI
deleteJames A. Schwindeman; Alex Kosanovich; Timothy Kwok; Annabel Q. Ansel; James M. MacDougall; Sylvain Guizzetti; Jimmy Lauberteaux; Alexandra Bodnar; Elizabeth M. Dauncey; John Knight
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Structure Determination of Synthesized Nitrosamine Drug Substance-Related Impurities (NDSRIs) Using 3D ED/MicroED合成亚硝胺药物杂质（NDSRIs）的结构测定：采用3D ED/MicroED技术
deleteOrganic Process Research & Development
IF3.5
delete2025-12-03
delete0
PREAI
deleteKeiyo Nakai; Yuki Ejima; Takashi Kikuchi; Kuniyoshi Miki; Natsuki Hashimoto; Mitsuhisa Yamano
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Stereoselective Synthesis of TAFIa Inhibitors: Strategic Application of Asymmetric Hydrogenation for the API and Crystallization-Induced Asymmetric Transformation for Its Prodrug手性选择性合成TAFIa抑制剂：不对称氢化在活性药物成分（API）中的战略应用以及结晶诱导的不对称转化在其前药中的应用
deleteOrganic Process Research & Development
IF3.5
delete2025-11-13
delete0
PREAI
deleteTsuyoshi Ueda; Yuzo Abe; Kazutoshi Ukai; Takumi Nakajima; Motohiro Ito; Masaki Hayashi
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Process Development of the Novel LpxC Inhibitor T-1228. Part 4: Control of Mutagenic Impurities during API Synthesis新型LpxC抑制剂T-1228的工艺开发。第4部分：在API合成过程中对致突变杂质的控制
deleteOrganic Process Research & Development
IF3.5
delete2025-11-10
delete0
PREAI
deleteYusuke Nagato; Noriyuki Nakajima
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Nitrosamine Control: From Risk Assessment to Analytical Testing with Emphasis on Sample Preparation and Phase-Appropriate Method Validation亚硝胺控制：从风险评估到分析测试，重点在于样品制备和与阶段相适应的方法验证
deleteOrganic Process Research & Development
IF3.5
delete2025-11-07
delete0
deleteOAAI
deleteAbhijit Tarafder; Edwin Vega; Hilary P. Beck; Devon Mundal; Mitul Tilala; Silas Wang
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Implementing a Material-of-Construction Compatibility Evaluation Program to Support Pharmaceutical Manufacturing实施一项材料兼容性评估计划，以支持制药生产
deleteOrganic Process Research & Development
IF3.5
delete2025-11-05
delete0
PREAI
deleteThomas P. Vickery; Tao Chen; Eric L. Margelefsky
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Process Development of the Novel LpxC Inhibitor T-1228: Part 3: Optimization of the Deprotection Reaction and the Crystallization for the Final Step of API Synthesis新型LpxC抑制剂T-1228的工艺开发：第3部分：API合成最终步骤的去保护反应和结晶优化
deleteOrganic Process Research & Development
IF3.5
delete2025-11-05
delete0
PREAI
deleteYusuke Nagato; Yasutaka Baba; Muneo Shoji; Yuko Suzumura; Noriyuki Nakajima
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Route Development toward a Pyrazine Building Block to Enable Early Scale-Up Campaigns开发一种吡嗪砌块以实现早期规模化生产方案
deleteOrganic Process Research & Development
IF3.5
delete2025-11-03
delete0
PREAI
deletePeter J. Lindsay-Scott; Scott Boyd; Daniela Dimitrova; Laura Evans; Stuart Pearson
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Tetramethylchloroformamidinium Hexafluorophosphate–N-Methylimidazole Amidation in Water: Successes; Limitations; and a Regression Model for Prediction六氟磷酸四甲基氯代甲脒-N-甲基咪唑水相酰胺化：成功案例；局限性；及预测回归模型
deleteOrganic Process Research & Development
IF3.5
delete2025-10-31
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PREAI
deleteRichard J. Fox; Dung L. Golden; Caitlin C. Chartrand; Lauren N. Grant; William P. Gallagher; Matthew J. Goldfogel
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Identification of Tamsulosin-Dimeric Impurity; Leading to the Efficient Manufacturing Process of the Active Pharmaceutical Ingredient鉴定他达拉非-二聚体杂质；促成活性药物成分的高效制造工艺
deleteOrganic Process Research & Development
IF3.5
delete2025-10-30
delete0
PREAI
deleteSadayuki Maeda; Tetsuya Kawashima; Daijiro Hayashi; Tatsunori Sato; Hiroki Moriwaki; Kanji Meguro
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Environmentally Benign Synthesis of Anticancer Drug Lenalidomide环境友好型抗肿瘤药物来那度胺的合成
deleteOrganic Process Research & Development
IF3.5
delete2025-10-29
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PREAI
deleteRaj S. Wandre; Kirti Sharma; Ahemad M. Pathan; Maryam Nabi; Amol B. Gade
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A Sustainable Approach to ε-Lys Branched GLP-1 Analogs: Integrating Green SPPS; Metal-free Alloc Removal; Waste Minimization and TFA/PFAS-free Resin Cleavage可持续的ε-赖氨酸支链GLP-1类似物合成方法：整合绿色SPPS、无金属Alloc去除、废物最小化及TFA/PFAS-free树脂裂解
deleteOrganic Process Research & Development
IF3.5
delete2025-10-29
delete0
PREAI
deleteJan Pawlas; Johan Billing; Behabitu Tebikachew; Larisa Wahlström; Linda M. Haugaard-Kedström
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Membrane-Enabled In-Line Solvent Drying for Base-Catalyzed Condensations in API Manufacture膜辅助在线溶剂干燥在API制造中的碱催化缩合反应中的应用
deleteOrganic Process Research & Development
IF3.5
delete2025-10-27
delete0
PREAI
deleteJacob C. Hood; Timothy Stuk; Andrea Adamo; Colin Byrne; Matthew Bedore
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Continuous Flow Conversion of Primary Amides to Amines: Dual Functionality of Trichloroacetonitrile in Sequential Dehydration and Selective Hydrogenation初级酰胺的连续流动转化制备胺：三氯乙腈在顺序脱水与选择性氢化中的双重功能
deleteOrganic Process Research & Development
IF3.5
delete2025-10-27
delete0
PREAI
deleteKwihwan Kobayashi; Naoki Oka; Nagatoshi Koumura
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Impurity Qualification Thresholds: An IQ Survey on Emerging Industry Experience with Health Authority Feedback杂质鉴定阈值：关于新兴行业在监管机构反馈方面的IQ调查
deleteOrganic Process Research & Development
IF3.5
delete2025-10-27
delete0
PREAI
deleteJennifer Alleva; Kate Arnot; Elizabeth A. Martin; Alejandra Trejo-Martin; John Nicolette; Mayur S. Mitra; Teresa Wegesser; Kaushik Datta; Sathanandam S. Anand; Joel Bercu
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Process Safety in the Pharmaceutical Industry─Part III: Dust Hazard Evaluation制药行业过程安全─第三部分：粉尘危害评估
deleteOrganic Process Research & Development
IF3.5
delete2025-10-27
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PREAI
deleteAyman D. Allian; Onkar Manjrekar; Nisha P. Shah; Michael J. Toth; Han Xia
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Solvent Effects on Crystallization Kinetics: Investigating Trends across Scales; Methods; and Process Analytical Technologies溶剂效应对结晶动力学的影响：探究跨尺度趋势；方法；以及过程分析技术
deleteOrganic Process Research & Development
IF3.5
delete2025-10-24
delete0
deleteOAAI
deleteIbrahim Joel; Alpana A. Thorat; Kevin P. Girard; Gerard Capellades
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An Improved Synthetic Route to Drotaverine and Papaverine Using Substituted Nitrostyrenes as Key Intermediates以取代硝基苯乙烯为关键中间体合成盐酸曲马多和吗啡定的改进合成路线
deleteOrganic Process Research & Development
IF3.5
delete2025-10-24
delete0
PREAI
deleteSneh Lata; Ankit Mehta; Akanksha Gwasikoti; Raj K. Shirumalla
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Process Development of the Novel LpxC Inhibitor T-1228. Part 1: Synthesis of the Diol Fragment新型LpxC抑制剂T-1228的工艺开发。第一部分：二醇片段的合成。
deleteOrganic Process Research & Development
IF3.5
delete2025-10-23
delete0
PREAI
deleteYusuke Nagato; Yasutaka Baba; Muneo Shoji; Yuko Suzumura; Noriyuki Nakajima
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Development of a Scalable Manufacturing Synthesis for Enarodustat可缩放制造合成方法的开发用于Enarodustat
deleteOrganic Process Research & Development
IF3.5
delete2025-10-23
delete0
PREAI
deleteYosuke Ogoshi; Kazuyuki Sugimoto; Takashi Yamaguchi; Akira Suma; Takashi Ito; Dai Motoda; Takuya Matsui; Takashi Ogo; Hiroyuki Abe; Fumito Shimoma
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