.png){kind=icon}
返回
Pathological Tau Disrupts Ongoing Network Activity
.png){kind=icon}
OA
AI
DOI：10.1016/j.neuron.2015.01.025.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Pathological tau leads to dementia and neurodegeneration in tauopathies, including Alzheimer's disease. It has been shown to disrupt cellular and synaptic functions, yet its effects on the function of the intact neocortical network remain unknown. Using in vivo intracellular and extracellular recordings, we measured ongoing activity of neocortical pyramidal cells during various arousal states in the rTg4510 mouse model of tauopathy, prior to significant cell death, when only a fraction of the neurons show pathological tau. In transgenic mice, membrane potential oscillations are slower during slow-wave sleep and under anesthesia. Intracellular recordings revealed that these changes are due to longer Down states and state transitions of membrane potentials. Firing rates of transgenic neurons are reduced, and firing patterns within Up states are altered, with longer latencies and inter-spike intervals. By changing the activity patterns of a subpopulation of affected neurons, pathological tau reduces the activity of the neocortical network.
Keyword:
RTG4510 MOUSE MODEL
NEURONS IN-VIVO
PYRAMIDAL CELLS
TAUOPATHY
INHIBITION
CORTEX
NEURODEGENERATION
OSCILLATION
VARIABILITY
INTEGRATION
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
15
论文数:
1.4W
被引数:
9.9W
机构
引用论文
.png){kind=icon}
分享收藏
查看更多内容