PD-E2: a nano-scaled delivery for estradiol to decrease uterus damage and increase bone mineral density

doi:10.1039/d4tb02764g

2025-01-01

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DOI：10.1039/d4tb02764g

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众所周知，17β-雌二醇（E2）的特定应用之一是在激素替代疗法（HRT）中，但它能够诱导子宫腺囊肿。然而，导致子宫腺囊肿和骨量丢失的E2浓度尚不清楚。为更好地理解这一问题，我们使用卵巢切除（OVX）小鼠作为动物模型，并给予聚-α,β-dl-天冬氨酰-Lys偶联E2（PD-E2）作为骨靶向剂。HPLC-FT-MS分析显示，接受2.3 μmol kg⁻¹·d⁻¹ E2治疗的OVX小鼠子宫和股骨中的E2含量分别为0.62 ± 0.15 ng g⁻¹和0.31 ± 0.09 ng g⁻¹，而接受10 nmol kg⁻¹·d⁻¹ PD-E2治疗的OVX小鼠子宫和股骨中的E2含量分别为0 ± 0 ng g⁻¹和1.11 ± 0.27 ng g⁻¹。数据显示，当子宫中E2含量达到0.62 ± 0.15 ng g⁻¹时，子宫腺将形成囊肿；当股骨中E2含量低于0.31 ± 0.09 ng g⁻¹时，骨量丢失将显著。此外，本研究中报道的纳米级PD-E2剂为HRT提供了一种创新策略。

Keyword:

REPLACEMENT

HORMONE

THERAPY

SAFETY

期刊

Journal of Materials Chemistry B

IF:

5.7

论文数:

1.1W

被引数:

4.3W

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暂无机构信息

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