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Peptide hormone precursor processing: getting sorted?
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DOI：10.1016/S0303-7207(99)00129-X.png)
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摘要
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Processing of proproteins to biologically active peptides and, in the case of peptide hormones and neuropeptides, their sorting to granules of the regulated secretory pathway, requires the concerted action of a cascade of enzymes and chaperones. The purpose of this review is to summarize the recent emerging knowledge of how these molecules affect specific endocrine systems. This has come about through the study of gene knockout mice as well as endocrinopathies resulting from mutated genes in humans. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
Keyword:
proprotein convertase
carboxypeptidase
7B2
granin
期刊
IF:
3.6
论文数:
8.1K
被引数:
1.6W
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