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PharmVar GeneFocus: CYP2A6
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DOI：10.1002/cpt.3387.png)
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Abstract
En 中文
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the human CYP2A gene locus containing the highly polymorphic CYP2A6 gene. CYP2A6 plays a role in the metabolism of nicotine and various drugs. Thus, genetic variation can substantially contribute to the function of this enzyme and associated efficacy and safety. This GeneFocus provides an overview of the clinical significance of CYP2A6, including its genetic variation and function. We also highlight and discuss caveats in the identification and characterization of allelic variation of this complex pharmacogene, a prerequisite for accurate genotype determination and prediction of phenotype status.
Keywords:
NICOTINE METABOLITE RATIO
CYTOCHROME-P450 2A6
IN-VIVO
CIGARETTE-SMOKING
MESSENGER-RNA
LUNG-CANCER
COUMARIN 7-HYDROXYLATION
TRANSDERMAL NICOTINE
DISPOSITION KINETICS
GENETIC-VARIATION
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