PharmVar GeneFocus: CYP2D6

doi:10.1002/cpt.1643

2019-12-09

176

Charity Nofziger

Amy Turner

Katrin Sangkuhl

Michelle Whirl‐Carrillo

José A. G. Agúndez

John L. Black

Henry M. Dunnenberger

DOI：10.1002/cpt.1643

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摘要

En 中文

The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism of numerous drugs and, thus, can impact drug efficacy and safety. This GeneFocus provides a comprehensive overview and summary of CYP2D6 genetic variation and describes how the information provided by PharmVar is utilized by the Pharmacogenomics Knowledgebase (PharmGKB) and the Clinical Pharmacogenetics Implementation Consortium (CPIC).

Keyword:

PHARMACOGENETICS IMPLEMENTATION CONSORTIUM

DRUG-METABOLIZING-ENZYMES

HUMAN CYTOCHROME-P450 2D6

CLINICAL-SIGNIFICANCE

CPIC GUIDELINE

PHENOTYPE ASSIGNMENT

GENETIC-VARIATION

NO-CALL

ALLELE

DEBRISOQUINE

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Clinical Pharmacology and Therapeutics

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5.5

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8.6K

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