logo
科言猫学术研究的AI总结
language
手机端手机端
  • Phone Feature微信小程序
简体中文简体中文
notice消息通知
博客博客
delete
arrow
返回

PharmVar GeneFocus: CYP4F2

delete2024-08-13
delete2
delete
OA
AI
P
Pablo Zubiaur
C
Cristina Rodríguez‐Antona
E
Erin C. Boone
A
Ann K. Daly
E
Evangelia Eirini Tsermpini
L
Lubna Q. Khasawneh
K
Katrin Sangkuhl
J
Jorgé Duconge
M
Mariana Rodrigues Botton
J
Jessica Savieo
C
Charity Nofziger
M
Michelle Whirl‐Carrillo
T
Teri E. Klein
A
Andrea Gaedigk *
DOI：10.1002/cpt.3405delete
delete原文链接
delete分享
delete收藏
查看原文
摘要

摘要

En 中文
The Pharmacogene Variation Consortium (PharmVar) serves as a global repository providing star (*) allele nomenclature for the polymorphic human CYP4F2 gene. CYP4F2 genetic variation impacts the metabolism of vitamin K, which is associated with warfarin dose requirements, and the metabolism of drugs, such as imatinib or fingolimod, and certain endogenous compounds including vitamin E and eicosanoids. This GeneFocus provides a comprehensive overview and summary of CYP4F2 genetic variation including the characterization of 14 novel star alleles, CYP4F2*4 through *17. A description of how haplotype information cataloged by PharmVar is utilized by the Pharmacogenomics Knowledgebase (PharmGKB) and the Clinical Pharmacogenetics Implementation Consortium (CPIC) is also provided.
Keyword:
B-4 OMEGA-HYDROXYLASE
MAINTENANCE DOSE REQUIREMENT
NONGENETIC FACTORS
ARACHIDONIC-ACID
COMMON VARIANTS
HUMAN LIVER
ACENOCOUMAROL
POLYMORPHISMS
EXPRESSION
ASSOCIATION
AI总结

AI总结

对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。

期刊

C
Clinical Pharmacology and Therapeutics
IF:
5.5
论文数:
8.6K
被引数:
1.9W

机构

N
newcastle university - uk
学者数:
2.9W
论文数: 2.6W
被引数: 39
U
United Arab Emirates University
学者数:
8.8K
论文数: 7.4K
被引数: 10.0K
S
Stanford University
学者数:
9.6W
论文数: 8.2W
被引数: 17.0W
U
Universidade Federal do Rio Grande do Sul
学者数:
2.6W
论文数: 1.7W
被引数: 1.6W
C
ciber - centro de investigacion biomedica en red
学者数:
3.5W
论文数: 2.5W
被引数: 45
U
university of puerto rico
学者数:
6.3K
论文数: 4.3K
被引数: 17
D
Dalhousie University
学者数:
2.0W
论文数: 1.8W
被引数: 2.3W
H
hospital de la princesa
学者数:
3.7K
论文数: 2.6K
被引数: 3
University of Missouri System 封面图
University of Missouri System
学者数:
3.0W
论文数: 2.7W
被引数: 75
学者 查看更多机构
引用论文

引用论文

Frequencies of pharmacogenomic alleles across biogeographic groups in a large-scale biobank
errAMERICAN JOURNAL OF HUMAN GENETICS
IF8.1
err2023-10-01
err11
errOAAI
errLi, Binglan; Sangkuhl, Katrin; Whaley, Ryan; Woon, Mark; Keat, Karl; Whirl-Carrillo, Michelle; Ritchie, Marylyn D.; Klein, Teri E.
err分享
err收藏
Impact of the CYP4F2 p.V433M Polymorphism on Coumarin Dose Requirement: Systematic Review and Meta-Analysis
errCLINICAL PHARMACOLOGY & THERAPEUTICS
IF5.5
err2012-11-07
err67
errOAAI
errDanese, E.; Montagnana, M.; Johnson, J. A.; Rettie, A. E.; Zambon, C. F.; Lubitz, S. A.; Suarez-Kurtz, G.; Cavallari, L. H.; Zhao, L.; Huang, M.; Nakamura, Y.; Mushiroda, T.; Kringen, M. K.; Borgiani, P.; Ciccacci, C.; Au, N. T.; Langaee, T.; Siguret, V.; Loriot, M. A.; Sagreiya, H.; Altman, R. B.; Shahin, M. H. A.; Scott, S. A.; Khalifa, S. I.; Chowbay, B.; Suriapranata, I. M.; Teichert, M.; Stricker, B. H.; Taljaard, M.; Botton, M. R.; Zhang, J. E.; Pirmohamed, M.; Zhang, X.; Carlquist, J. F.; Horne, B. D.; Lee, M. T. M.; Pengo, V.; Guidi, G. C.; Minuz, P.; Fava, C.
err分享
err收藏
Expression of CYP4F2 in human liver and kidney: Assessment using targeted peptide antibodies
errARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
IF3
err2008-10-01
err39
errOAAI
errHirani, Vandana; Yarovoy, Anton; Kozeska, Anita; Magnusson, Ronald P.; Lasker, Jerome M.
err分享
err收藏
Looping variation observed in environmental gamma-ray measurement due to atmospheric radon daughters
errNuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
IF0
err1987-03-01
err0
PREAI
errShigeru Okabe; Tsuguo Nishikawa; Masayoshi Aoki; Motoyuki Yamada
err分享
err收藏
Recommendations for Clinical Warfarin Genotyping Allele Selection A Report of the Association for Molecular Pathology and the College of American Pathologists
errJOURNAL OF MOLECULAR DIAGNOSTICS
IF3.4
err2020-07-01
err39
errOAAI
errPratt, Victoria M.; Cavallari, Larisa H.; Del Tredici, Andria L.; Hachad, Houda; Ji, Yuan; Kalman, Lisa V.; Ly, Reynold C.; Moyer, Ann M.; Scott, Stuart A.; Whirl-Carrillo, Michelle; Weck, Karen E.
err分享
err收藏
PharmVar GeneFocus: CYP2C9
errCLINICAL PHARMACOLOGY & THERAPEUTICS
IF5.5
err2021-07-12
err45
errOAAI
errSangkuhl, Katrin; Claudio-Campos, Karla; Cavallari, Larisa H.; Agundez, Jose A. G.; Whirl-Carrillo, Michelle; Duconge, Jorge; Del Tredici, Andria L.; Wadelius, Mia; Botton, Mariana Rodrigues; Woodahl, Erica L.; Scott, Stuart A.; Klein, Teri E.; Pratt, Victoria M.; Daly, Ann K.; Gaedigk, Andrea
err分享
err收藏
Predictive Engineering Tools for Injection-Molded Long-Carbon-Fiber Thermoplastic Composites (Quarterly Report)
err
IF0
err2013-04-01
err0
errOAAI
errBa Nguyen; Kevin Simmons
err分享
err收藏
Combination of Genome-Wide Polymorphisms and Copy Number Variations of Pharmacogenes in Koreans
errJOURNAL OF PERSONALIZED MEDICINE
IF3
err2021-01-07
err5
errOAAI
errHan, Nayoung; Oh, Jung Mi; Kim, In-Wha
err分享
err收藏
Vitamin K-dependent carboxylation of coagulation factors: insights from a cell-based functional study
errHAEMATOLOGICA
IF7.9
err2019-10-17
err20
errOAAI
errHao, Zhenyu; Jin, Da-Yun; Stafford, Darrel W.; Tie, Jian-Ke
err分享
err收藏
The V433M variant of the CYP4F2 is associated with ischemic stroke in male swedes beyond its effect on blood pressure
errHYPERTENSION
IF8.2
err2008-08-01
err121
errOAAI
errFava, Cristiano; Montagnana, Martina; Almgren, Peter; Rosberg, Lena; Lippi, Giuseppe; Hedblad, Bo; Engstroem, Gunnar; Berglund, Goeran; Minuz, Pietro; Melander, Olle
err分享
err收藏
学者 查看更多内容