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Polydopamine based ion-selective nanosensor for electrolyte sensing
DOI:10.1007/s00604-026-07859-1.png)
摘要
En 中文
离子选择性纳米传感器能够实现活细胞内离子的监测,但现有的大多数光纤传感器平台依赖有限的基质材料,且功能化和稳定性受限。本研究将聚多巴胺(PDA)纳米颗粒与离子载体基离子选择性传感原理相结合,生成用于钾离子(K⁺)和钙离子(Ca²⁺)检测的稳定、可调谐纳米传感器。PDA基质通过其带负电荷的微环境增强了传感器的灵敏度,并使表面能够直接与半胱胺和谷胱甘肽进行功能化修饰,以促进细胞相互作用和摄取。该纳米传感器表现出宽动态范围(K⁺为0.1 mM-0.1 M,Ca²⁺为1 µM-0.1 M)、对竞争离子的高选择性、优异的胶体稳定性和极低的细胞毒性。重要的是,基于PDA的纳米传感器能够实现活细胞内K⁺动态的实时可视化。这些结果确立了PDA作为一种有前景且可适配的基质材料,适用于下一代生物环境中的离子选择性纳米传感器。
Keyword:
Ion-selective nanosensor
Polydopamine
Ionophore
Live cells
期刊
M
IF:
5.3
论文数:
9.4K
被引数:
2.3W
机构
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