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Post-translational modifications regulate microtubule function

delete2003-12-01
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Stefan Westermann
K
Klaus Weber
DOI:10.1038/nrm1260delete
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摘要

摘要

En 中文
The alphabeta-tubulin heterodimer, the building block of microtubules, is subject to a large number of post-translational modifications, comparable in diversity to the intensively studied histone modifications. Although these unusual modifications are conserved throughout evolution, their functions have remained almost completely elusive. Recently, however, important advances in the understanding of how tubulin modifications regulate function and organization have been made.
Keyword:
TUBULIN-TYROSINE LIGASE
ALPHA-TUBULIN
BETA-TUBULIN
IN-VIVO
RAT-BRAIN
INTERMEDIATE-FILAMENTS
AXONEMAL MICROTUBULES
GIARDIA-LAMBLIA
KIDNEY-DISEASE
MOUSE-BRAIN
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期刊

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Nature Reviews Molecular Cell Biology
IF:
90.2
论文数:
4.1K
被引数:
7.3W

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