Precisely Defined Polymers for Efficient Gene Delivery

Dongsheng He

doi:10.1007/s41061-017-0183-y

2018-01-15

PRE

DOI：10.1007/s41061-017-0183-y

原文链接

摘要

En 中文

Gene therapy requires successful delivery of therapeutic nucleic acids into target cells; thus, efficient and safe gene delivery carriers are crucial to its success. Although many polymeric materials have shown their potential as effective nucleic acid carriers, the inherent heterogeneity and polydispersity of these polymers hinder their application in clinical studies because of difficulties in their further precise modification, structure-activity relationship study, as well as consistent manufacturing. Therefore, precisely defined polymers, with potential for sitespecific optimization according to structure-activity relationship information and highly controllable production, have been extensively investigated. In this review, we focus on the design and development of precisely defined polymers for efficient gene delivery, illustrated with examples including dendrimers, peptide-based polymers, and sequence-defined oligoaminoamide oligomers.

Keyword:

Gene delivery

Defined polymers

Dendrimer

Peptide

Sequencedefined oligoaminoamide

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期刊

Topics in Current Chemistry

IF:

8.8

论文数:

637

被引数:

6.5K

机构

China Pharmaceutical University

学者数:

1.4K

论文数: 296

被引数: 0

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