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Programmable full-adder computations in communicating three-dimensional cell cultures
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DOI：10.1038/NMETH.4505.png)
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Synthetic biologists have advanced the design of trigger-inducible gene switches and their assembly into input-programmable circuits that enable engineered human cells to perform arithmetic calculations reminiscent of electronic circuits. By designing a versatile plug-and-play molecular-computation platform, we have engineered nine different cell populations with genetic programs, each of which encodes a defined computational instruction. When assembled into 3D cultures, these engineered cell consortia execute programmable multicellular full-adder logics in response to three trigger compounds.
Keyword:
MAMMALIAN-CELLS
GENE-EXPRESSION
LIVING CELLS
RNA
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