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PROTAC-ing tuberculosis
DOI:10.1038/s41589-024-01624-2.png)
摘要
En 中文
Targeted protein degradation has emerged as a promising approach in drug discovery, harnessing a cell's intrinsic machinery to eliminate disease-related proteins. Now, a study paves the way to translating this technology into potential anti-mycobacterial therapies, by exploiting the bacterial protein-degradation complex.
期刊
IF:
13.7
论文数:
4.8K
被引数:
3.3W
机构
引用论文
Exploring a potential Achilles heel ofMycobacterium tuberculosis: defining the ClpC1 interactome
FEBS JOURNAL
IF4.2
Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation
NATURE COMMUNICATIONS
IF15.7
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