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Protective role of cyanidin-3-O-glucoside in 2-amino-3-methylimidazo[4,5-f]quinoline-induced gastrointestinal injury: focus on oxidative stress, inflammation, intestinal barrier and gut microbiota
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DOI：10.1002/jsfa.70852.png)
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Abstract
En 中文
2-Amino-3-methylimidazo[4,5-f]quinoline (IQ), a typical heterocyclic amine, is a common dietary carcinogen raising gastric and colorectal cancer risks. As an abundant anthocyanin monomer with established antioxidant and anti-inflammatory activities, cyanidin-3-O-glucoside (C3G) might attenuate IQ toxicity. Nevertheless, whether and how C3G alleviates IQ-triggered gastrointestinal damage remains unclarified. This study investigated the protective mechanisms of C3G against IQ-induced gastrointestinal injury in mice using biochemical assays, histopathology, western blotting, 16S rRNA sequencing, and molecular simulation.
Keywords:
heterocyclic amines
anthocyanins
inflammation
antioxidant
gut microbiota
molecular dynamics simulation
Journal
IF:
3.5
Papers:
1.4W
Citations:
4.1W
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Cited Papers