Protein matchmaking through representation learning

Michael Heinzinger

doi:10.1016/j.cels.2021.09.007

2021-10-01

Michael Heinzinger

Christian Dallago *

Burkhard Rost

DOI：10.1016/j.cels.2021.09.007

原文链接

原文求助

摘要

En 中文

Sledzieski, Singh, Cowen, and Berger employ representation learning to predict protein interactions and associations, additionally identifying binding residues between protein pairs. Generalizability is showcased by training on one organism while evaluating on others. The work exemplifies how transfer of AI-learned representations can advance knowledge in molecular biology.

期刊

Cell Systems

IF:

7.7

论文数:

1.4K

被引数:

1.0W

机构

Technical University of Munich

学者数:

5.2W

论文数: 3.9W

被引数: 6.2W

引用论文

Biological structure and function emerge from scaling unsupervised learning to 250 million protein sequences 生物结构和功能源于扩展无监督学习以2.5亿蛋白质序列

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2021-04-05

1.1K

OAAI

Rives, Alexander; Meier, Joshua; Sercu, Tom; Goyal, Siddharth; Lin, Zeming; Liu, Jason; Guo, Demi; Ott, Myle; Zitnick, C. Lawrence; Ma, Jerry; Fergus, Rob

Embeddings from deep learning transfer GO annotations beyond homology

SCIENTIFIC REPORTS

IF3.9

2021-01-13

OAAI

Littmann, Maria; Heinzinger, Michael; Dallago, Christian; Olenyi, Tobias; Rost, Burkhard

Unified rational protein engineering with sequence-based deep representation learning 基于序列的深度表示学习的统一理性蛋白质工程

NATURE METHODS

IF32.1

2019-10-21

645

OAAI

Alley, Ethan C.; Khimulya, Grigory; Biswas, Surojit; AlQuraishi, Mohammed; Church, George M.

Poultry Shelf-Life Enhancing Potential of Nanofibers and Nanoparticles Containing Porphyra dioica Extracts 含有紫菜提取物的纳米纤维和纳米颗粒的家禽货架期延长潜力

Coatings

IF0

2020-03-26

OAAI

João Reboleira; Pedro Adão; Sara F. C. Guerreiro; Juliana R. Dias; Rui Ganhão; Susana Mendes; Mariana Andrade; Fernanda Vilarinho; Ana Sanches-Silva; Artur Mateus; Nuno Alves; Susana Bernardino

Efficacy and Tolerability of Prostaglandin Analogs

Journal of Glaucoma

IF0

2008-12-01

PREAI

Florent Aptel; Michel Cucherat; Philippe Denis

IID 2018 update: context-specific physical protein-protein interactions in human, model organisms and domesticated species

NUCLEIC ACIDS RESEARCH

IF13.1

2018-11-08

151

OAAI

Kotlyar, Max; Pastrello, Chiara; Malik, Zara; Jurisica, Igor

SARS-CoV-2 structural coverage map reveals viral protein assembly, mimicry, and hijacking mechanisms SARS-CoV-2结构覆盖图揭示了病毒蛋白的组装，模仿和劫持机制

MOLECULAR SYSTEMS BIOLOGY

IF7.7

2021-09-14

OAAI

O'Donoghue, Sean, I; Schafferhans, Andrea; Sikta, Neblina; Stolte, Christian; Kaur, Sandeep; Ho, Bosco K.; Anderson, Stuart; Procter, James B.; Dallago, Christian; Bordin, Nicola; Adcock, Matt; Rost, Burkhard

没有更多内容