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Recoding in bacteriophages and bacterial IS elements
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DOI：10.1016/j.tig.2006.01.005.png)
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Dynamic shifts between open reading frames and the redefinition of codon meaning at specific sites, programmed by signals in mRNA, permits versatility of gene expression. Such alterations are characteristic of organisms in all domains of life and serve a variety of functional purposes. In this article, we concentrate on programmed ribosomal frameshifting, stop codon read-through and transcriptional slippage in the decoding of phage genes and bacterial mobile elements. Together with their eukaryotic counterparts, the genes encoding these elements are the richest known source of nonstandard decoding. Recent analyses revealed several novel sequences encoding programmed alterations in gene decoding and provide a glimpse of the emerging picture.
Keyword:
PROGRAMMED TRANSLATIONAL FRAMESHIFT
SITE TRANSFER-RNA
GENE-EXPRESSION
TRANSCRIPTIONAL SLIPPAGE
INSERTION-SEQUENCE
ESCHERICHIA-COLI
RELEASE FACTOR-2
PROTEIN
CODONS
SIGNAL
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16.3
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3.4K
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1.5W
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Programmed translational-1 frameshifting on hexanucleotide motifs and the wobble properties of tRNAs.png)
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OAAI分享收藏Transcriptional slippage in bacteria: distribution in sequenced genomes and utilization in IS element gene expressionGENOME BIOLOGY
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