.png){kind=icon}
返回
Saxitoxin
.png){kind=icon}
PRE
AI
DOI：10.1002/anie.201308235.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
The paralytic agent (+)-saxitoxin (STX), most commonly associated with oceanic red tides and shellfish poisoning, is a potent inhibitor of electrical conduction in cells. Its nefarious effects result from inhibition of voltage-gated sodium channels (Na(V)s), the obligatory proteins responsible for the initiation and propagation of action potentials. In the annals of ion channel research, the identification and characterization of Na(V)s trace to the availability of STX and an allied guanidinium derivative, tetrodotoxin. The mystique of STX is expressed in both its function and form, as this uniquely compact dication boasts more heteroatoms than carbon centers. This Review highlights both the chemistry and chemical biology of this fascinating natural product, and offers a perspective as to how molecular design and synthesis may be used to explore Na-V structure and function.
Keyword:
chemical probes
chemical synthesis
guanidinium toxin
neurobiology
sodium ion channel
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
16.9
论文数:
5.7W
被引数:
53.0W
机构
引用论文
分享收藏
International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.png)
PHARMACOLOGICAL REVIEWS
PHARMACOLOGICAL REVIEWSIF17.3
PREAI
分享收藏
查看更多内容