Scanning system for angle-resolved low-coherence interferometry

Zachary A. Steelman

doi:10.1364/OL.42.004581

2017-11-03

Zachary A. Steelman *

Derek Ho

Kengyeh K. Chu

Adam Wax

DOI：10.1364/OL.42.004581

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摘要

En 中文

Angle-resolved low-coherence interferometry (a/LCI) detects precancer by enabling depth-resolved measurements of nuclear morphology in vivo. A significant limitation of a/LCI is the point-probe nature of the method, sampling <0.5 mm(2) before probe relocation is necessary. In this work, we demonstrate a scanning method capable of assessing an area > 100 mm(2) without repositioning. By utilizing a reflection-only three-optic rotator prism and a two-axis scanning mirror, we demonstrate radial scans of a sample with a linear range of 12 mm and a full rotational range of 180 degrees. Use of this design will improve the diagnostic utility of a/LCI for wide-area screening of tissue health. (C) 2017 Optical Society of America

Keyword:

NUCLEAR MORPHOLOGY

BARRETTS-ESOPHAGUS

CLINICAL DETECTION

DYSPLASIA

EPITHELIUM

期刊

Optics Letters

IF:

3.3

论文数:

4.0W

被引数:

7.6W

机构

Duke University

学者数:

6.3W

论文数: 5.7W

被引数: 6.5W

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