Selective autophagy bears bone

Milana Fraiberg

doi:10.15252/embj.2020105965

2020-07-27

Milana Fraiberg

Zvulun Elazar *

DOI：10.15252/embj.2020105965

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摘要

En 中文

The endoplasmic reticulum (ER) is a dynamic intracellular network responsible for folding and maturation of organellar and secreted proteins. Selective autophagy of ER (ER-phagy) is emerging as an essential process that maintains proteostasis in the ER and is regulated by growth conditions. In this issue, Cinque et al (2020) show that fibroblast growth factor 18 (FGF18) specifically activates ER-phagy through a TFEB/TFE-dependent transcriptional regulation of the ER-phagy receptor Fam134b, a process essential for bone ossification and skeletal development.

Keyword:

ER-PHAGY

GROWTH

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期刊

EMBO Journal

IF:

8.3

论文数:

1.3W

被引数:

6.3W

机构

Weizmann Institute of Science

学者数:

1.3W

论文数: 1.1W

被引数: 2.3W

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