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Silent Learning
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DOI：10.1016/j.cub.2018.09.012.png)
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Abstract
En 中文
We introduce the concept of silent learning-the capacity to learn despite neuronal cell-firing being largely absent. This idea emerged from thinking about dendritic computation [1, 2] and examining whether the encoding, expression, and retrieval of hippocampal-dependent memory could be dissociated using the intrahippocampal infusion of pharmacological compounds. We observed that very modest enhancement of GABAergic inhibition with low-dose muscimol blocked both cell-firing and the retrieval of an already-formed memory but left induction of long-term potentiation (LTP) and new spatial memory encoding intact (silent learning). In contrast, blockade of hippocampal NMDA receptors by intrahippocampal D-AP5 impaired both the induction of LTP and encoding but had no effect on memory retrieval. Blockade of AMPA receptors by CNQX impaired excitatory synaptic transmission and cell-firing and both memory encoding and retrieval. Thus, in keeping with the synaptic plasticity and memory hypothesis [3], the hippocampal network can mediate new memory encoding when LTP induction is intact even under conditions in which somatic cell-firing is blocked.
Keywords:
LONG-TERM POTENTIATION
ASPARTATE RECEPTOR ANTAGONIST
WATER-MAZE PROCEDURE
ON-DEMAND PLATFORM
SYNAPTIC PLASTICITY
SELECTIVE IMPAIRMENT
DORSAL HIPPOCAMPUS
NMDA RECEPTORS
SPATIAL MEMORY
PLACE FIELDS
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