Single cell behavior in T cell differentiation

Jan Rohr

doi:10.1016/j.it.2014.02.006

2014-04-01

PRE

DOI：10.1016/j.it.2014.02.006

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摘要

En 中文

Upon primary infection, naive T cells that recognize their cognate antigen become activated, proliferate, and simultaneously differentiate into various subsets. A long-standing question in the field has been how this cellular diversification is achieved. Conceptually, diverse cellular output may either arise from every single cell or only from populations of naive cells. Furthermore, such diversity may either be driven by cell-intrinsic heterogeneity or by external, niche-derived signals. In this review, we discuss how recently developed technologies have allowed the analysis of the mechanisms underlying T cell diversification at the single cell level. In addition, we outline the implications of this work on our understanding of the formation of immunological memory, and describe a number of unresolved key questions in this field.

Keyword:

T cell differentiation

single-cell tracking

asymmetric cell division

population asymmetry

cellular heterogeneity

cell-extrinsic signals

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期刊

Trends in Immunology

IF:

13.9

论文数:

2.7K

被引数:

1.7W

机构

Harvard University

学者数:

26.5W

论文数: 22.0W

被引数: 28.7W

Netherlands Cancer Institute

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10.0K

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