.png){kind=icon}
返回
Solid-State Quad-Nanopore Array for High-Resolution Single-Molecule Analysis and Discrimination
.png){kind=icon}
PRE
AI
DOI：10.1002/adma.202211399.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
The ability to detect and distinguish biomolecules at the single-molecule level is at the forefront of today's biomedicine and analytical chemistry research. Increasing the dwell time of individual biomolecules in the sensing spot can greatly enhance the sensitivity of single-molecule methods. This is particularly important in solid-state nanopore sensing, where the detection of small molecules is often limited by the transit dwell time and insufficient temporal resolution. Here, a quad-nanopore is introduced, a square array of four nanopores (with a space interval of 30-50 nm) to improve the detection sensitivity through electric field manipulation in the access region. It is shown that dwell times of short DNA strands (200 bp) are prolonged in quad-nanopores as compared to single nanopores of the same diameter. The dependence of dwell times on the quad-pore spacing is investigated and it is found that the retarding effect increases with decreasing space intervals. Furthermore, ultra-short DNA (50 bp) detection is demonstrated using a 10 nm diameter quad-nanopore array, which is hardly detected by a single nanopore. Finally, the general utility of quad-nanopores has been verified by successful discrimination of two kinds of small molecules, metal-organic cage and bovine serum albumin (BSA).
Keyword:
biosensors
finite-element simulations
nanotechnology
single-molecule detection
solid-state nanopores
期刊
IF:
26.8
论文数:
3.4W
被引数:
46.0W
机构
引用论文
分享收藏Rapid fabrication of uniformly sized nanopores and nanopore arrays for parallel DNA analysis.png)
ADVANCED MATERIALS
ADVANCED MATERIALSIF26.8
PREAI
分享收藏Electrostatic focusing of unlabelled DNA into nanoscale pores using a salt gradientNATURE NANOTECHNOLOGY
OAAI
NATURE NANOTECHNOLOGYIF34.9
OAAI分享收藏Impact of Fuel and Injection Timing on Partially Premixed Charge Compression Ignition Combustion
PREAI
分享收藏Plasmonic Nanopores for Single-Molecule Detection and Manipulation: Toward Sequencing Applications用于单分子检测和操作的等离子体纳米孔: 面向测序应用NANO LETTERSOAAI
NANO LETTERSIF9.1
OAAI分享收藏Single-molecule sensing of peptides and nucleic acids by engineered aerolysin nanoporesNATURE COMMUNICATIONSOAAI
NATURE COMMUNICATIONSIF15.7
OAAI分享收藏Metal-Organic Cage as Single-Molecule Carrier for Solid-State Nanopore Analysis金属有机笼作为单分子载体用于固态纳米孔分析SMALL METHODS
SMALL METHODSIF9.1
PREAI
分享收藏Electro-Optical Detection of Single Molecules Based on Solid-State Nanopores基于固态纳米孔的单分子电光检测SMALL STRUCTURESOAAI
SMALL STRUCTURESIF11.3
OAAI分享收藏
查看更多内容